@article{fdcadcf12ba04798ad0823a213585c1d,
title = "Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis",
abstract = "Keap1 and Nrf2 proteins work in concert to regulate redox balance in the cells. Pyaram et al. report that Keap1 governs NKT cell development and peripheral homeostasis by regulating proliferation and apoptosis. In an Nrf2-dependent manner, Keap1 also controls NKT cell metabolism, including glucose uptake and ROS.",
keywords = "NKT cells, antioxidant system, cell metabolism, innate T cells, reactive oxygen species",
author = "Kalyani Pyaram and Ajay Kumar and Kim, {Yeung Hyen} and Sanjeev Noel and Reddy, {Sekhar P.} and Hamid Rabb and Chang, {Cheong Hee}",
note = "Funding Information: We would like to thank Ms. Chauna Black for diligent maintenance and genetic screening of the mice. We also thank the Chang lab members for their valuable input to the manuscript. We acknowledge the NIH Tetramer Facility for providing us with the mouse CD1d tetramers. This work was supported in part by NIH grants AI121156 (to C.-H.C.) and DK111209 (to H.R.). K.P. visualized and conceived the project, performed experiments, interpreted the data, and wrote the manuscript. C.-H.C. secured funding, supervised the project, and wrote the manuscript. A.K. performed experiments and interpreted the data. Y.-H.K and S.N. performed experiments and provided feedback. H.R. and S.P.R. provided reagents and feedback. The authors declare no competing interests. Funding Information: We would like to thank Ms. Chauna Black for diligent maintenance and genetic screening of the mice. We also thank the Chang lab members for their valuable input to the manuscript. We acknowledge the NIH Tetramer Facility for providing us with the mouse CD1d tetramers. This work was supported in part by NIH grants AI121156 (to C.-H.C.) and DK111209 (to H.R.). Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = apr,
day = "16",
doi = "10.1016/j.celrep.2019.03.052",
language = "English (US)",
volume = "27",
pages = "699--707.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}