Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis

Kalyani Pyaram, Ajay Kumar, Yeung Hyen Kim, Sanjeev Noel, Sekhar P. Reddy, Hamid Rabb, Cheong Hee Chang

Research output: Contribution to journalArticlepeer-review

Abstract

Keap1 and Nrf2 proteins work in concert to regulate redox balance in the cells. Pyaram et al. report that Keap1 governs NKT cell development and peripheral homeostasis by regulating proliferation and apoptosis. In an Nrf2-dependent manner, Keap1 also controls NKT cell metabolism, including glucose uptake and ROS.

Original languageEnglish (US)
Pages (from-to)699-707.e4
JournalCell Reports
Volume27
Issue number3
DOIs
StatePublished - Apr 16 2019

Keywords

  • NKT cells
  • antioxidant system
  • cell metabolism
  • innate T cells
  • reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint

Dive into the research topics of 'Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis'. Together they form a unique fingerprint.

Cite this