KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 Update

Michael Rocco, John T. Daugirdas, Thomas A. Depner, Jula Inrig, Rajnish Mehrotra, Michael V. Rocco, Rita S. Suri, Daniel E. Weiner, Nancy Greer, Areef Ishani, Roderick MacDonald, Carin Olson, Indulis Rutks, Yelena Slinin, Timothy J. Wilt, Holly Kramer, Michael J. Choi, Milagros Samaniego-Picota, Paul J. Scheel, Kerry WillisJessica Joseph, Laura Brereton

Research output: Contribution to journalArticle


The National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (KDOQI) has provided evidence-based guidelines for all stages of chronic kidney disease (CKD) and related complications since 1997. The 2015 update of the KDOQI Clinical Practice Guideline for Hemodialysis Adequacy is intended to assist practitioners caring for patients in preparation for and during hemodialysis. The literature reviewed for this update includes clinical trials and observational studies published between 2000 and March 2014. New topics include high-frequency hemodialysis and risks; prescription flexibility in initiation timing, frequency, duration, and ultrafiltration rate; and more emphasis on volume and blood pressure control. Appraisal of the quality of the evidence and the strength of recommendations followed the Grading of Recommendation Assessment, Development, and Evaluation (GRADE) approach. Limitations of the evidence are discussed and specific suggestions are provided for future research.

Original languageEnglish (US)
Pages (from-to)884-930
Number of pages47
JournalAmerican Journal of Kidney Diseases
Issue number5
StatePublished - Nov 1 2015



  • Clinical Practice Guideline
  • Hemodialysis
  • adequacy
  • evidence-based recommendation
  • hemodialysis frequency
  • hemodialysis prescription
  • hemofiltration
  • initiation
  • treatment time
  • urea modeling

ASJC Scopus subject areas

  • Nephrology

Cite this

Rocco, M., Daugirdas, J. T., Depner, T. A., Inrig, J., Mehrotra, R., Rocco, M. V., Suri, R. S., Weiner, D. E., Greer, N., Ishani, A., MacDonald, R., Olson, C., Rutks, I., Slinin, Y., Wilt, T. J., Kramer, H., Choi, M. J., Samaniego-Picota, M., Scheel, P. J., ... Brereton, L. (2015). KDOQI Clinical Practice Guideline for Hemodialysis Adequacy: 2015 Update. American Journal of Kidney Diseases, 66(5), 884-930. https://doi.org/10.1053/j.ajkd.2015.07.015