Abstract
We report detailed chromosome banding analysis of six cases of ovarian adenocarcinoma cultured 24-96 hr in a recently developed bioassay for clonogenic tumor cells. The results of G and C banding revealed a variety of chromosome changes including the observation of a simple deletion for a portion of the long arm of chromosome #6, del(6) (pter → q15-21:), in tumor cells from four of six patients. Our study indicates that short-term agar culture can provide a valuable tool in the study of tumor cell karyology. A comparison of our results with previously published studies suggests that in addition to alterations of chromosome #1, the deletion of 6q may represent a characteristic chromosomal aberration in ovarian carcinoma.
Original language | English (US) |
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Pages (from-to) | 279-291 |
Number of pages | 13 |
Journal | Cancer Genetics and Cytogenetics |
Volume | 3 |
Issue number | 4 |
DOIs | |
State | Published - Jun 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research