Karyotypic analysis of human ovarian carcinoma cells cloned in short term agar culture

Jeffrey M. Trent, Sydney E. Salmon

Research output: Contribution to journalArticlepeer-review

Abstract

We report detailed chromosome banding analysis of six cases of ovarian adenocarcinoma cultured 24-96 hr in a recently developed bioassay for clonogenic tumor cells. The results of G and C banding revealed a variety of chromosome changes including the observation of a simple deletion for a portion of the long arm of chromosome #6, del(6) (pter → q15-21:), in tumor cells from four of six patients. Our study indicates that short-term agar culture can provide a valuable tool in the study of tumor cell karyology. A comparison of our results with previously published studies suggests that in addition to alterations of chromosome #1, the deletion of 6q may represent a characteristic chromosomal aberration in ovarian carcinoma.

Original languageEnglish (US)
Pages (from-to)279-291
Number of pages13
JournalCancer Genetics and Cytogenetics
Volume3
Issue number4
DOIs
StatePublished - Jun 1981

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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