Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4) perturbs the G1-S cell cycle progression via deregulation of the cyclin D1 gene

Hye Ra Lee, Jaba Mitra, Stacy Lee, Shou Jiang Gao, Tae Kwang Oh, Myung Hee Kim, Taekjip Ha, Jae U. Jung

Research output: Contribution to journalArticlepeer-review

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter, suppressing the G1-S cell cycle progression and enhancing KSHV replication. This shows that KSHV vIRF4 suppresses host G1-S transition, possibly providing an intracellular milieu favorable for its replication.

Original languageEnglish (US)
Pages (from-to)1139-1143
Number of pages5
JournalJournal of virology
Volume90
Issue number2
DOIs
StatePublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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