Kallmann syndrome: MR evaluation of olfactory system

D. M. Yousem, W. J.D. Turner, C. Li, P. J. Snyder, R. L. Doty, D. P. Bick, A. Ballabio

Research output: Contribution to journalArticlepeer-review


PURPOSE: To describe the MR appearance of the olfactory bulbs and tracts and temporal lobes in patients with Kallmann syndrome, a disorder characterized by hypogonadotropic hypogonadism and anosmia. METHODS: High- resolution MR scans with a surface coil placed over the nasion were performed in two patients with Kallmann syndrome. Coronal 3-mm thick contiguous sections were obtained through the olfactory bulbs and tracts. MR scans included volumetric analysis of the bulbs, tracts, temporal lobes, and hippocampi. RESULTS: No olfactory bulbs or tracts could be identified in patients with Kallmann syndrome. In comparison, the olfactory bulbs and tracts were identifiable in seven healthy volunteers. The temporal lobe and hippocampal volumes were comparable between control subjects and Kallmann patients. CONCLUSIONS: High-resolution surface-coil MR can identify the absence of olfactory bulbs and tracts in patients with Kallmann syndrome. Normal olfactory bulbs and tracts are easily discerned with surface-coil imaging.

Original languageEnglish (US)
Pages (from-to)839-843+852
JournalAmerican Journal of Neuroradiology
Issue number4
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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