KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2

Jin Tang Dong, Pattie W. Lamb, Carrie W. Rinker-Schaeffer, Jasminka Vukanovic, Tomohiko Ichikawa, John Tod Isaacs, J. Carl Barrett

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Abstract

A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1, was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionary conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.

Original languageEnglish (US)
Pages (from-to)884-886
Number of pages3
JournalScience
Volume268
Issue number5212
Publication statusPublished - May 12 1995

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Cite this

Dong, J. T., Lamb, P. W., Rinker-Schaeffer, C. W., Vukanovic, J., Ichikawa, T., Isaacs, J. T., & Barrett, J. C. (1995). KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science, 268(5212), 884-886.