Juvenile xanthogranuloma presenting as a testicular mass in infancy: A clinical and pathologic study of three cases

Kristina Suson, Ranjiv Mathews, Jeffrey D. Goldstein, Louis P. Dehner

Research output: Contribution to journalArticle

Abstract

Juvenile xanthogranulomas (JXG) is a histiocytic disorder whose most common clinical presentation is a solitary cutaneous nodule in a child under 5 years of age, but it has come to be recognized that solitary extracutaneous lesions may present in a number of sites, including the soft tissues and various organs. Involvement of the genitourinary tract has been documented in children with multifocal or systemic JXG. The current report describes our experience with 3 cases of JXG presenting as a solitary mass in the testicle of infants between 2.5 and 13 months without manifestations of JXG elsewhere. The masses were intratesticular and had an infiltrative pattern of interstitial growth by mononuclear, histiocyte-like cells with replacement of seminiferous tubules and involvement of the epididymis whose pattern resembled leukemic and lymphomatous involvement of the testis. Because extracutaneous lesions of JXG may have few or no Touton giant cells, immunohistochemistry is an important adjunct to the histopathologic diagnosis. One of the previous 2 cases in the literature of JXG of the testis recurred after partial resection without an orchiectomy. Neither of the 2 youngest patients has experienced a local recurrence of JXG elsewhere in excess of 1 year since the original orchiectomy. The oldest patient, who was treated with partial orchiectomy, remains free of recurrence after 3 months of follow-up. Though uncommon, JXG joins several other distinctive neoplasms presenting in the infantile testis.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalPediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Volume13
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Juvenile Xanthogranuloma
Orchiectomy
Testis
Recurrence
Seminiferous Tubules
Histiocytes
Clinical Studies
Epididymis
Giant Cells
Immunohistochemistry
Skin

Keywords

  • Histiocytosis
  • Juvenile xanthogranulomas
  • Orchiectomy
  • Testicle

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Juvenile xanthogranuloma presenting as a testicular mass in infancy : A clinical and pathologic study of three cases. / Suson, Kristina; Mathews, Ranjiv; Goldstein, Jeffrey D.; Dehner, Louis P.

In: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, Vol. 13, No. 1, 01.2010, p. 39-45.

Research output: Contribution to journalArticle

@article{e370a6978c8c4f0db6a6dbd328d57e6b,
title = "Juvenile xanthogranuloma presenting as a testicular mass in infancy: A clinical and pathologic study of three cases",
abstract = "Juvenile xanthogranulomas (JXG) is a histiocytic disorder whose most common clinical presentation is a solitary cutaneous nodule in a child under 5 years of age, but it has come to be recognized that solitary extracutaneous lesions may present in a number of sites, including the soft tissues and various organs. Involvement of the genitourinary tract has been documented in children with multifocal or systemic JXG. The current report describes our experience with 3 cases of JXG presenting as a solitary mass in the testicle of infants between 2.5 and 13 months without manifestations of JXG elsewhere. The masses were intratesticular and had an infiltrative pattern of interstitial growth by mononuclear, histiocyte-like cells with replacement of seminiferous tubules and involvement of the epididymis whose pattern resembled leukemic and lymphomatous involvement of the testis. Because extracutaneous lesions of JXG may have few or no Touton giant cells, immunohistochemistry is an important adjunct to the histopathologic diagnosis. One of the previous 2 cases in the literature of JXG of the testis recurred after partial resection without an orchiectomy. Neither of the 2 youngest patients has experienced a local recurrence of JXG elsewhere in excess of 1 year since the original orchiectomy. The oldest patient, who was treated with partial orchiectomy, remains free of recurrence after 3 months of follow-up. Though uncommon, JXG joins several other distinctive neoplasms presenting in the infantile testis.",
keywords = "Histiocytosis, Juvenile xanthogranulomas, Orchiectomy, Testicle",
author = "Kristina Suson and Ranjiv Mathews and Goldstein, {Jeffrey D.} and Dehner, {Louis P.}",
year = "2010",
month = "1",
doi = "10.2350/09-06-0665-OA.1",
language = "English (US)",
volume = "13",
pages = "39--45",
journal = "Pediatric and Developmental Pathology",
issn = "1093-5266",
publisher = "Society for Pediatric Pathology",
number = "1",

}

TY - JOUR

T1 - Juvenile xanthogranuloma presenting as a testicular mass in infancy

T2 - A clinical and pathologic study of three cases

AU - Suson, Kristina

AU - Mathews, Ranjiv

AU - Goldstein, Jeffrey D.

AU - Dehner, Louis P.

PY - 2010/1

Y1 - 2010/1

N2 - Juvenile xanthogranulomas (JXG) is a histiocytic disorder whose most common clinical presentation is a solitary cutaneous nodule in a child under 5 years of age, but it has come to be recognized that solitary extracutaneous lesions may present in a number of sites, including the soft tissues and various organs. Involvement of the genitourinary tract has been documented in children with multifocal or systemic JXG. The current report describes our experience with 3 cases of JXG presenting as a solitary mass in the testicle of infants between 2.5 and 13 months without manifestations of JXG elsewhere. The masses were intratesticular and had an infiltrative pattern of interstitial growth by mononuclear, histiocyte-like cells with replacement of seminiferous tubules and involvement of the epididymis whose pattern resembled leukemic and lymphomatous involvement of the testis. Because extracutaneous lesions of JXG may have few or no Touton giant cells, immunohistochemistry is an important adjunct to the histopathologic diagnosis. One of the previous 2 cases in the literature of JXG of the testis recurred after partial resection without an orchiectomy. Neither of the 2 youngest patients has experienced a local recurrence of JXG elsewhere in excess of 1 year since the original orchiectomy. The oldest patient, who was treated with partial orchiectomy, remains free of recurrence after 3 months of follow-up. Though uncommon, JXG joins several other distinctive neoplasms presenting in the infantile testis.

AB - Juvenile xanthogranulomas (JXG) is a histiocytic disorder whose most common clinical presentation is a solitary cutaneous nodule in a child under 5 years of age, but it has come to be recognized that solitary extracutaneous lesions may present in a number of sites, including the soft tissues and various organs. Involvement of the genitourinary tract has been documented in children with multifocal or systemic JXG. The current report describes our experience with 3 cases of JXG presenting as a solitary mass in the testicle of infants between 2.5 and 13 months without manifestations of JXG elsewhere. The masses were intratesticular and had an infiltrative pattern of interstitial growth by mononuclear, histiocyte-like cells with replacement of seminiferous tubules and involvement of the epididymis whose pattern resembled leukemic and lymphomatous involvement of the testis. Because extracutaneous lesions of JXG may have few or no Touton giant cells, immunohistochemistry is an important adjunct to the histopathologic diagnosis. One of the previous 2 cases in the literature of JXG of the testis recurred after partial resection without an orchiectomy. Neither of the 2 youngest patients has experienced a local recurrence of JXG elsewhere in excess of 1 year since the original orchiectomy. The oldest patient, who was treated with partial orchiectomy, remains free of recurrence after 3 months of follow-up. Though uncommon, JXG joins several other distinctive neoplasms presenting in the infantile testis.

KW - Histiocytosis

KW - Juvenile xanthogranulomas

KW - Orchiectomy

KW - Testicle

UR - http://www.scopus.com/inward/record.url?scp=77949683991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949683991&partnerID=8YFLogxK

U2 - 10.2350/09-06-0665-OA.1

DO - 10.2350/09-06-0665-OA.1

M3 - Article

C2 - 19968486

AN - SCOPUS:77949683991

VL - 13

SP - 39

EP - 45

JO - Pediatric and Developmental Pathology

JF - Pediatric and Developmental Pathology

SN - 1093-5266

IS - 1

ER -