Abstract
In situ hybridization using cDNAs complementary to specific regions of the mRNAs encoding 3 members of the jun transcription factor gene family and c-fos reveals modest levels of hybridization over superficial laminae of the nucleus caudalis of the spinal tract of the trigeminal in sections taken from unstimulated brains. Jun B expression is markedly and rapidly enhanced ipsilateral to electrical stimulation of the trigeminal ganglion. C-fos mRNA levels also show changes, especially after higher intensity stimulation. Smaller alterations in c-jun (jun A) and jun D do not reach statistical significance. In each instance of altered expression, more neurons express hybridization densities above background levels after stimulation. Parallels between these alterations and changes in the expression of preproenkephalin in these same neuronal populations are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 133-141 |
| Number of pages | 9 |
| Journal | Molecular Brain Research |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1991 |
| Externally published | Yes |
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Keywords
- C-jun
- Gene regulation
- Jun B
- Jun D
- Preproenkephalin
- Transcription factor
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
Cite this
Jun B, c-jun, jun D and c-fos mRNAs in nucleus caudalis neurons : rapid selective enhancement by afferent stimulation. / Uhl, George R.; Walther, Donna; Nishimori, Toshikazu; Gabriella Buzzi, M.; Moskowitz, Michael A.
In: Molecular Brain Research, Vol. 11, No. 2, 1991, p. 133-141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Jun B, c-jun, jun D and c-fos mRNAs in nucleus caudalis neurons
T2 - rapid selective enhancement by afferent stimulation
AU - Uhl, George R.
AU - Walther, Donna
AU - Nishimori, Toshikazu
AU - Gabriella Buzzi, M.
AU - Moskowitz, Michael A.
PY - 1991
Y1 - 1991
N2 - In situ hybridization using cDNAs complementary to specific regions of the mRNAs encoding 3 members of the jun transcription factor gene family and c-fos reveals modest levels of hybridization over superficial laminae of the nucleus caudalis of the spinal tract of the trigeminal in sections taken from unstimulated brains. Jun B expression is markedly and rapidly enhanced ipsilateral to electrical stimulation of the trigeminal ganglion. C-fos mRNA levels also show changes, especially after higher intensity stimulation. Smaller alterations in c-jun (jun A) and jun D do not reach statistical significance. In each instance of altered expression, more neurons express hybridization densities above background levels after stimulation. Parallels between these alterations and changes in the expression of preproenkephalin in these same neuronal populations are discussed.
AB - In situ hybridization using cDNAs complementary to specific regions of the mRNAs encoding 3 members of the jun transcription factor gene family and c-fos reveals modest levels of hybridization over superficial laminae of the nucleus caudalis of the spinal tract of the trigeminal in sections taken from unstimulated brains. Jun B expression is markedly and rapidly enhanced ipsilateral to electrical stimulation of the trigeminal ganglion. C-fos mRNA levels also show changes, especially after higher intensity stimulation. Smaller alterations in c-jun (jun A) and jun D do not reach statistical significance. In each instance of altered expression, more neurons express hybridization densities above background levels after stimulation. Parallels between these alterations and changes in the expression of preproenkephalin in these same neuronal populations are discussed.
KW - C-jun
KW - Gene regulation
KW - Jun B
KW - Jun D
KW - Preproenkephalin
KW - Transcription factor
UR - http://www.scopus.com/inward/record.url?scp=0025895159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025895159&partnerID=8YFLogxK
U2 - 10.1016/0169-328X(91)90115-E
DO - 10.1016/0169-328X(91)90115-E
M3 - Article
C2 - 1661810
AN - SCOPUS:0025895159
VL - 11
SP - 133
EP - 141
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -