Jun B, c-jun, jun D and c-fos mRNAs in nucleus caudalis neurons: rapid selective enhancement by afferent stimulation

George R. Uhl, Donna Walther, Toshikazu Nishimori, M. Gabriella Buzzi, Michael A. Moskowitz

Research output: Contribution to journalArticlepeer-review

Abstract

In situ hybridization using cDNAs complementary to specific regions of the mRNAs encoding 3 members of the jun transcription factor gene family and c-fos reveals modest levels of hybridization over superficial laminae of the nucleus caudalis of the spinal tract of the trigeminal in sections taken from unstimulated brains. Jun B expression is markedly and rapidly enhanced ipsilateral to electrical stimulation of the trigeminal ganglion. C-fos mRNA levels also show changes, especially after higher intensity stimulation. Smaller alterations in c-jun (jun A) and jun D do not reach statistical significance. In each instance of altered expression, more neurons express hybridization densities above background levels after stimulation. Parallels between these alterations and changes in the expression of preproenkephalin in these same neuronal populations are discussed.

Original languageEnglish (US)
Pages (from-to)133-141
Number of pages9
JournalMolecular Brain Research
Volume11
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • C-jun
  • Gene regulation
  • Jun B
  • Jun D
  • Preproenkephalin
  • Transcription factor

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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