Journey from jumping genes to gene therapy

Research output: Contribution to journalArticle

Abstract

Gene therapy for cancer is a still evolving approach that resulted from a long history of studies into genetic modification of organisms. The fascination with manipulating gene products has spanned hundreds if not thousands of years, beginning with observations of the hereditary nature of traits in plants and culminating to date in the alteration of genetic makeup in humans via modern technology. From early discoveries noting the potential for natural mobility of genetic material to the culmination of clinical trials in a variety of disease, gene transfer has had an eventful and sometimes tumultuous course. Within the present review is a brief history of the biology of gene transfer, how it came to be applied to genetic diseases, and its early applications to cancer therapies. Some of the different types of methods used to modify cells, the theories behind the approaches, and some of the limitations encountered along the way are reviewed.

Original languageEnglish (US)
Pages (from-to)509-518
Number of pages10
JournalCritical reviews in oncogenesis
Volume20
Issue number5-6
DOIs
StatePublished - Jan 1 2015

Keywords

  • Cancer
  • Gene therapy
  • Gene transfer
  • Genetic disease
  • Oncogenes

ASJC Scopus subject areas

  • Cancer Research

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