TY - GEN
T1 - Joint reconstruction of activity and attenuation map using LM SPECT emission data
AU - Jha, Abhinav K.
AU - Clarkson, Eric
AU - Kupinski, Matthew A.
AU - Barrett, Harrison H.
PY - 2013
Y1 - 2013
N2 - Attenuation and scatter correction in single photon emission computed tomography (SPECT) imaging often requires a computed tomography (CT) scan to compute the attenuation map of the patient. This results in increased radiation dose for the patient, and also has other disadvantages such as increased costs and hardware complexity. Attenuation in SPECT is a direct consequence of Compton scattering, and therefore, if the scattered photon data can give information about the attenuation map, then the CT scan may not be required. In this paper, we investigate the possibility of joint reconstruction of the activity and attenuation map using list- mode (LM) SPECT emission data, including the scattered-photon data. We propose a path-based formalism to process scattered-photon data. Following this, we derive analytic expressions to compute the Craḿer-Rao bound (CRB) of the activity and attenuation map estimates, using which, we can explore the fundamental limit of information-retrieval capacity from LM SPECT emission data. We then suggest a maximum-likelihood (ML) scheme that uses the LM emission data to jointly reconstruct the activity and attenuation map. We also propose an expectation-maximization (EM) algorithm to compute the ML solution.
AB - Attenuation and scatter correction in single photon emission computed tomography (SPECT) imaging often requires a computed tomography (CT) scan to compute the attenuation map of the patient. This results in increased radiation dose for the patient, and also has other disadvantages such as increased costs and hardware complexity. Attenuation in SPECT is a direct consequence of Compton scattering, and therefore, if the scattered photon data can give information about the attenuation map, then the CT scan may not be required. In this paper, we investigate the possibility of joint reconstruction of the activity and attenuation map using list- mode (LM) SPECT emission data, including the scattered-photon data. We propose a path-based formalism to process scattered-photon data. Following this, we derive analytic expressions to compute the Craḿer-Rao bound (CRB) of the activity and attenuation map estimates, using which, we can explore the fundamental limit of information-retrieval capacity from LM SPECT emission data. We then suggest a maximum-likelihood (ML) scheme that uses the LM emission data to jointly reconstruct the activity and attenuation map. We also propose an expectation-maximization (EM) algorithm to compute the ML solution.
KW - Activity and attenuation map
KW - Cramer-rao bound
KW - Fisher information
KW - Joint reconstruction
KW - List-mode data
KW - Maximum likelihood expectation maximization
KW - SPECT
UR - http://www.scopus.com/inward/record.url?scp=84878315036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878315036&partnerID=8YFLogxK
U2 - 10.1117/12.2008111
DO - 10.1117/12.2008111
M3 - Conference contribution
C2 - 26236067
AN - SCOPUS:84878315036
SN - 9780819494429
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2013
T2 - Medical Imaging 2013: Physics of Medical Imaging
Y2 - 11 February 2013 through 14 February 2013
ER -