@inproceedings{635cd914579143b6902aff54cc92a3fe,
title = "Joint intensity fusion image synthesis applied to multiple sclerosis lesion segmentation",
abstract = "We propose a new approach to Multiple Sclerosis lesion segmentation that utilizes synthesized images. A new method of image synthesis is considered: joint intensity fusion (JIF). JIF synthesizes an image from a library of deformably registered and intensity normalized atlases. Each location in the synthesized image is a weighted average of the registered atlases; atlas weights vary spatially. The weights are determined using the joint label fusion (JLF) framework. The primary methodological contribution is the application of JLF to MRI signal directly rather than labels. Synthesized images are then used as additional features in a lesion segmentation task using the OASIS classifier, a logistic regression model on intensities from multiple modalities. The addition of JIF synthesized images improved the Dice-Sorensen coefficient (relative to manually drawn gold standards) of lesion segmentations over the standard model segmentations by 0.0462 ± 0.0050 (mean ± standard deviation) at optimal threshold over all subjects and 10 separate training/testing folds.",
author = "Fleishman, {Greg M.} and Alessandra Valcarcel and Dzung Pham and Snehashis Roy and Calabresi, {Peter A.} and Paul Yushkevich and Shinohara, {Russell T.} and Ipek Oguz",
note = "Funding Information: grants: R01-NS094456, R01-EB017255, R01-NS085211, R21-NS093349, R01-NS082347, R01-NS070906 and by the National Multiple Sclerosis Society grant: RG-1507-05243. Funding Information: Acknowledgements. This work supported by the National Institutes of Health Publisher Copyright: {\textcopyright} Springer International Publishing AG, part of Springer Nature 2018.; 3rd International Workshop on Brainlesion, BrainLes 2017 Held in Conjunction with Medical Image Computing for Computer Assisted Intervention , MICCAI 2017 ; Conference date: 14-09-2017 Through 14-09-2017",
year = "2018",
doi = "10.1007/978-3-319-75238-9_4",
language = "English (US)",
isbn = "9783319752372",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "43--54",
editor = "Bjoern Menze and Alessandro Crimi and Hugo Kuijf and Mauricio Reyes and Spyridon Bakas",
booktitle = "Brainlesion",
}