Joint impact of physical activity and family history on the development of diabetes among urban adults in Mainland China: A pooled analysis of community-based prospective cohort studies

Fei Xu, Youfa Wang, Robert S. Ware, Lap Ah Tse, Zhiyong Wang, Xin Hong, David W. Dunstan, Neville Owen

Research output: Contribution to journalArticlepeer-review

Abstract

To examine the joint influences of physical activity (PA) and family history (FH) of diabetes on subsequent type 2 diabetes (T2D), the authors pooled and analyzed data from 2 community-based urban adult prospective cohort studies in 2011 in Nanjing, China. Among 4550 urban participants, the 3-year cumulative incidence of T2D was 5.1%. After adjustment for potential confounders, compared with those with FH+ and insufficient PA, the adjusted odds ratio (95% confidence interval) of developing T2D was 0.42 (0.18, 0.98) for participants with sufficient PA and FH+, 0.32 (0.22, 0.46) for participants with insufficient PA and FH-, and 0.15 (0.08, 0.28) for participants with sufficient PA and FH-. Such significant graduated associations between PA/FH and risk of developing T2D were also identified in either men or women, separately. Sufficient PA and FH- may jointly reduce the risk of developing T2D in urban Chinese adults.

Original languageEnglish (US)
Pages (from-to)NP372-NP381
JournalAsia-Pacific Journal of Public Health
Volume27
Issue number2
DOIs
StatePublished - Mar 4 2015

Keywords

  • China
  • cohort study
  • family history of diabetes
  • physical activity
  • type 2 diabetes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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