Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer

A bivariate spline model approach

Gioia Di Credico, Valeria Edefonti, Jerry Polesel, Francesco Pauli, Nicola Torelli, Diego Serraino, Eva Negri, Daniele Luce, Isabelle Stucker, Keitaro Matsuo, Paul Brennan, Marta Vilensky, Leticia Fernandez, Maria Paula Curado, Ana Menezes, Alexander W. Daudt, Rosalina Koifman, Victor Wunsch-Filho, Ivana Holcatova, Wolfgang Ahrens & 58 others Pagona Lagiou, Lorenzo Simonato, Lorenzo Richiardi, Claire Healy, Kristina Kjaerheim, David I. Conway, Tatiana V. Macfarlane, Peter Thomson, Antonio Agudo, Ariana Znaor, Leonardo F. Boaventura Rios, Tatiana N. Toporcov, Silvia Franceschi, Rolando Herrero, Joshua Muscat, Andrew F. Olshan, Jose P. Zevallos, Carlo La Vecchia, Deborah M. Winn, Erich M. Sturgis, Guojun Li, Eleonora Fabianova, Jolanda Lissowska, Dana Mates, Peter Rudnai, Oxana Shangina, Beata Swiatkowska, Kirsten Moysich, Zuo Feng Zhang, Hal Morgenstern, Fabio Levi, Elaine Smith, Philip Lazarus, Cristina Bosetti, Werner Garavello, Karl Kelsey, Michael McClean, Heribert Ramroth, Chu Chen, Stephen M. Schwartz, Thomas L. Vaughan, Tongzhang Zheng, Gwenn Menvielle, Stefania Boccia, Gabriella Cadoni, Richard B. Hayes, Mark Purdue, Maura Gillison, Stimson Schantz, Guo Pei Yu, Hermann Brenner, Gypsyamber D'Souza, Neil D. Gross, Shu Chun Chuang, Paolo Boffetta, Mia Hashibe, Yuan Chin Amy Lee, Luigino Dal Maso

Research output: Contribution to journalArticle

Abstract

Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

Original languageEnglish (US)
Pages (from-to)47-57
Number of pages11
JournalOral Oncology
Volume94
DOIs
StatePublished - Jul 1 2019

Fingerprint

Pharyngeal Neoplasms
Head and Neck Neoplasms
Smoking
Mouth
Laryngeal Neoplasms
Tobacco Products
Smoking Cessation
Case-Control Studies
Epidemiology
Joints
Logistic Models
Odds Ratio
Alcohols

Keywords

  • Bivariate spline models
  • Cigarette smoking duration
  • Cigarette smoking intensity
  • Head and neck cancer
  • INHANCE
  • Laryngeal cancer
  • Oral cavity and pharyngeal cancers

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer : A bivariate spline model approach. / Di Credico, Gioia; Edefonti, Valeria; Polesel, Jerry; Pauli, Francesco; Torelli, Nicola; Serraino, Diego; Negri, Eva; Luce, Daniele; Stucker, Isabelle; Matsuo, Keitaro; Brennan, Paul; Vilensky, Marta; Fernandez, Leticia; Curado, Maria Paula; Menezes, Ana; Daudt, Alexander W.; Koifman, Rosalina; Wunsch-Filho, Victor; Holcatova, Ivana; Ahrens, Wolfgang; Lagiou, Pagona; Simonato, Lorenzo; Richiardi, Lorenzo; Healy, Claire; Kjaerheim, Kristina; Conway, David I.; Macfarlane, Tatiana V.; Thomson, Peter; Agudo, Antonio; Znaor, Ariana; Boaventura Rios, Leonardo F.; Toporcov, Tatiana N.; Franceschi, Silvia; Herrero, Rolando; Muscat, Joshua; Olshan, Andrew F.; Zevallos, Jose P.; La Vecchia, Carlo; Winn, Deborah M.; Sturgis, Erich M.; Li, Guojun; Fabianova, Eleonora; Lissowska, Jolanda; Mates, Dana; Rudnai, Peter; Shangina, Oxana; Swiatkowska, Beata; Moysich, Kirsten; Zhang, Zuo Feng; Morgenstern, Hal; Levi, Fabio; Smith, Elaine; Lazarus, Philip; Bosetti, Cristina; Garavello, Werner; Kelsey, Karl; McClean, Michael; Ramroth, Heribert; Chen, Chu; Schwartz, Stephen M.; Vaughan, Thomas L.; Zheng, Tongzhang; Menvielle, Gwenn; Boccia, Stefania; Cadoni, Gabriella; Hayes, Richard B.; Purdue, Mark; Gillison, Maura; Schantz, Stimson; Yu, Guo Pei; Brenner, Hermann; D'Souza, Gypsyamber; Gross, Neil D.; Chuang, Shu Chun; Boffetta, Paolo; Hashibe, Mia; Lee, Yuan Chin Amy; Dal Maso, Luigino.

In: Oral Oncology, Vol. 94, 01.07.2019, p. 47-57.

Research output: Contribution to journalArticle

Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, MP, Menezes, A, Daudt, AW, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, DI, Macfarlane, TV, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, LF, Toporcov, TN, Franceschi, S, Herrero, R, Muscat, J, Olshan, AF, Zevallos, JP, La Vecchia, C, Winn, DM, Sturgis, EM, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, ZF, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, McClean, M, Ramroth, H, Chen, C, Schwartz, SM, Vaughan, TL, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, RB, Purdue, M, Gillison, M, Schantz, S, Yu, GP, Brenner, H, D'Souza, G, Gross, ND, Chuang, SC, Boffetta, P, Hashibe, M, Lee, YCA & Dal Maso, L 2019, 'Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach', Oral Oncology, vol. 94, pp. 47-57. https://doi.org/10.1016/j.oraloncology.2019.05.006
Di Credico, Gioia ; Edefonti, Valeria ; Polesel, Jerry ; Pauli, Francesco ; Torelli, Nicola ; Serraino, Diego ; Negri, Eva ; Luce, Daniele ; Stucker, Isabelle ; Matsuo, Keitaro ; Brennan, Paul ; Vilensky, Marta ; Fernandez, Leticia ; Curado, Maria Paula ; Menezes, Ana ; Daudt, Alexander W. ; Koifman, Rosalina ; Wunsch-Filho, Victor ; Holcatova, Ivana ; Ahrens, Wolfgang ; Lagiou, Pagona ; Simonato, Lorenzo ; Richiardi, Lorenzo ; Healy, Claire ; Kjaerheim, Kristina ; Conway, David I. ; Macfarlane, Tatiana V. ; Thomson, Peter ; Agudo, Antonio ; Znaor, Ariana ; Boaventura Rios, Leonardo F. ; Toporcov, Tatiana N. ; Franceschi, Silvia ; Herrero, Rolando ; Muscat, Joshua ; Olshan, Andrew F. ; Zevallos, Jose P. ; La Vecchia, Carlo ; Winn, Deborah M. ; Sturgis, Erich M. ; Li, Guojun ; Fabianova, Eleonora ; Lissowska, Jolanda ; Mates, Dana ; Rudnai, Peter ; Shangina, Oxana ; Swiatkowska, Beata ; Moysich, Kirsten ; Zhang, Zuo Feng ; Morgenstern, Hal ; Levi, Fabio ; Smith, Elaine ; Lazarus, Philip ; Bosetti, Cristina ; Garavello, Werner ; Kelsey, Karl ; McClean, Michael ; Ramroth, Heribert ; Chen, Chu ; Schwartz, Stephen M. ; Vaughan, Thomas L. ; Zheng, Tongzhang ; Menvielle, Gwenn ; Boccia, Stefania ; Cadoni, Gabriella ; Hayes, Richard B. ; Purdue, Mark ; Gillison, Maura ; Schantz, Stimson ; Yu, Guo Pei ; Brenner, Hermann ; D'Souza, Gypsyamber ; Gross, Neil D. ; Chuang, Shu Chun ; Boffetta, Paolo ; Hashibe, Mia ; Lee, Yuan Chin Amy ; Dal Maso, Luigino. / Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer : A bivariate spline model approach. In: Oral Oncology. 2019 ; Vol. 94. pp. 47-57.
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title = "Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach",
abstract = "Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.",
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TY - JOUR

T1 - Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer

T2 - A bivariate spline model approach

AU - Di Credico, Gioia

AU - Edefonti, Valeria

AU - Polesel, Jerry

AU - Pauli, Francesco

AU - Torelli, Nicola

AU - Serraino, Diego

AU - Negri, Eva

AU - Luce, Daniele

AU - Stucker, Isabelle

AU - Matsuo, Keitaro

AU - Brennan, Paul

AU - Vilensky, Marta

AU - Fernandez, Leticia

AU - Curado, Maria Paula

AU - Menezes, Ana

AU - Daudt, Alexander W.

AU - Koifman, Rosalina

AU - Wunsch-Filho, Victor

AU - Holcatova, Ivana

AU - Ahrens, Wolfgang

AU - Lagiou, Pagona

AU - Simonato, Lorenzo

AU - Richiardi, Lorenzo

AU - Healy, Claire

AU - Kjaerheim, Kristina

AU - Conway, David I.

AU - Macfarlane, Tatiana V.

AU - Thomson, Peter

AU - Agudo, Antonio

AU - Znaor, Ariana

AU - Boaventura Rios, Leonardo F.

AU - Toporcov, Tatiana N.

AU - Franceschi, Silvia

AU - Herrero, Rolando

AU - Muscat, Joshua

AU - Olshan, Andrew F.

AU - Zevallos, Jose P.

AU - La Vecchia, Carlo

AU - Winn, Deborah M.

AU - Sturgis, Erich M.

AU - Li, Guojun

AU - Fabianova, Eleonora

AU - Lissowska, Jolanda

AU - Mates, Dana

AU - Rudnai, Peter

AU - Shangina, Oxana

AU - Swiatkowska, Beata

AU - Moysich, Kirsten

AU - Zhang, Zuo Feng

AU - Morgenstern, Hal

AU - Levi, Fabio

AU - Smith, Elaine

AU - Lazarus, Philip

AU - Bosetti, Cristina

AU - Garavello, Werner

AU - Kelsey, Karl

AU - McClean, Michael

AU - Ramroth, Heribert

AU - Chen, Chu

AU - Schwartz, Stephen M.

AU - Vaughan, Thomas L.

AU - Zheng, Tongzhang

AU - Menvielle, Gwenn

AU - Boccia, Stefania

AU - Cadoni, Gabriella

AU - Hayes, Richard B.

AU - Purdue, Mark

AU - Gillison, Maura

AU - Schantz, Stimson

AU - Yu, Guo Pei

AU - Brenner, Hermann

AU - D'Souza, Gypsyamber

AU - Gross, Neil D.

AU - Chuang, Shu Chun

AU - Boffetta, Paolo

AU - Hashibe, Mia

AU - Lee, Yuan Chin Amy

AU - Dal Maso, Luigino

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

AB - Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

KW - Bivariate spline models

KW - Cigarette smoking duration

KW - Cigarette smoking intensity

KW - Head and neck cancer

KW - INHANCE

KW - Laryngeal cancer

KW - Oral cavity and pharyngeal cancers

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