Joint associations between genetic variants and reproductive factors in glioma risk among women

Sophia S. Wang, Patricia Hartge, Meredith Yeager, Tania Carreón, Avima M. Ruder, Martha Linet, Peter D. Inskip, Amanda Black, Ann W. Hsing, Michael Alavanja, Laura Beane-Freeman, Mahboobeh Safaiean, Stephen J. Chanock, Preetha Rajaraman

Research output: Contribution to journalArticle

Abstract

In a pooled analysis of 4 US epidemiologic studies (1993-2001), the authors evaluated the role of 5 female reproductive factors in 357 women with glioma and 822 controls. The authors further evaluated the independent association between 5 implicated gene variants and glioma risk among the study population, as well as the joint associations of female reproductive factors (ages at menarche and menopause, menopausal status, use of oral contraceptives, and menopausal hormone therapy) and these gene variants on glioma risk. Risk estimates were calculated as odds ratios and 95% confidence intervals that were adjusted for age, race, and study. Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population. Compared with women who had an early age at menarche (

Original languageEnglish (US)
Pages (from-to)901-908
Number of pages8
JournalAmerican Journal of Epidemiology
Volume174
Issue number8
DOIs
StatePublished - Oct 15 2011
Externally publishedYes

Fingerprint

Glioma
Menarche
Age Factors
Oral Contraceptives
Menopause
Genetic Therapy
Population
Genes
Epidemiologic Studies
Odds Ratio
Hormones
Confidence Intervals

Keywords

  • genes
  • glioma
  • menstrual cycle
  • polymorphism, single nucleotide
  • reproduction
  • women

ASJC Scopus subject areas

  • Epidemiology

Cite this

Wang, S. S., Hartge, P., Yeager, M., Carreón, T., Ruder, A. M., Linet, M., ... Rajaraman, P. (2011). Joint associations between genetic variants and reproductive factors in glioma risk among women. American Journal of Epidemiology, 174(8), 901-908. https://doi.org/10.1093/aje/kwr184

Joint associations between genetic variants and reproductive factors in glioma risk among women. / Wang, Sophia S.; Hartge, Patricia; Yeager, Meredith; Carreón, Tania; Ruder, Avima M.; Linet, Martha; Inskip, Peter D.; Black, Amanda; Hsing, Ann W.; Alavanja, Michael; Beane-Freeman, Laura; Safaiean, Mahboobeh; Chanock, Stephen J.; Rajaraman, Preetha.

In: American Journal of Epidemiology, Vol. 174, No. 8, 15.10.2011, p. 901-908.

Research output: Contribution to journalArticle

Wang, SS, Hartge, P, Yeager, M, Carreón, T, Ruder, AM, Linet, M, Inskip, PD, Black, A, Hsing, AW, Alavanja, M, Beane-Freeman, L, Safaiean, M, Chanock, SJ & Rajaraman, P 2011, 'Joint associations between genetic variants and reproductive factors in glioma risk among women', American Journal of Epidemiology, vol. 174, no. 8, pp. 901-908. https://doi.org/10.1093/aje/kwr184
Wang, Sophia S. ; Hartge, Patricia ; Yeager, Meredith ; Carreón, Tania ; Ruder, Avima M. ; Linet, Martha ; Inskip, Peter D. ; Black, Amanda ; Hsing, Ann W. ; Alavanja, Michael ; Beane-Freeman, Laura ; Safaiean, Mahboobeh ; Chanock, Stephen J. ; Rajaraman, Preetha. / Joint associations between genetic variants and reproductive factors in glioma risk among women. In: American Journal of Epidemiology. 2011 ; Vol. 174, No. 8. pp. 901-908.
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