Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

Chen Wu, Zhaoming Wang, Xin Song, Xiao Shan Feng, Christian C. Abnet, Jie He, Nan Hu, Xian Bo Zuo, Wen Tan, Qimin Zhan, Zhibin Hu, Zhonghu He, Weihua Jia, Yifeng Zhou, Kai Yu, Xiao Ou Shu, Jian Min Yuan, Wei Zheng, Xue Ke Zhao, She Gan GaoZhi Qing Yuan, Fu You Zhou, Zong Min Fan, Ji Li Cui, Hong Li Lin, Xue Na Han, Bei Li, Xi Chen, Sanford M. Dawsey, Linda Liao, Maxwell P. Lee, Ti Ding, You Lin Qiao, Zhihua Liu, Yu Liu, Dianke Yu, Jiang Chang, Lixuan Wei, Yu Tang Gao, Woon Puay Koh, Yong Bing Xiang, Ze Zhong Tang, Jin Hu Fan, Jing Jing Han, Sheng Li Zhou, Peng Zhang, Dong Yun Zhang, Yuan Yuan, Ying Huang, Chunling Liu, Kan Zhai, Yan Qiao, Guangfu Jin, Chuanhai Guo, Jianhua Fu, Xiaoping Miao, Changdong Lu, Haijun Yang, Chaoyu Wang, William A. Wheeler, Mitchell Gail, Meredith Yeager, Jeff Yuenger, Er Tao Guo, Ai Li Li, Wei Zhang, Xue Min Li, Liang Dan Sun, Bao Gen Ma, Yan Li, Sa Tang, Xiu Qing Peng, Jing Liu, Amy Hutchinson, Kevin Jacobs, Carol Giffen, Laurie Burdette, Joseph F. Fraumeni, Hongbing Shen, Yang Ke, Yixin Zeng, Tangchun Wu, Peter Kraft, Charles C. Chung, Margaret A. Tucker, Zhi Chao Hou, Ya Li Liu, Yan Long Hu, Li Wang, Guo Yuan, Li Sha Chen, Xiao Liu, Teng Ma, Hui Meng, Xin Min Li, Jian Wei Ku, Ying Fa Zhou, Liu Qin Yang, Zhou Wang, Yin Li, Qirenwang Qige, Wen Jun Yang, Guang Yan Lei, Long Qi Chen, En Min Li, Ling Yuan, Wen Bin Yue, Ran Wang, Lu Wen Wang, Xue Ping Fan, Fang Heng Zhu, Wei Xing Zhao, Yi Min Mao, Mei Zhang, Guo Lan Xing, Ji Lin Li, Min Han, Jing Li Ren, Bin Liu, Shu Wei Ren, Qing Peng Kong, Feng Li, Ilyar Sheyhidin, Wu Wei, Yan Rui Zhang, Chang Wei Feng, Jin Wang, Yu Hua Yang, Hong Zhang Hao, Qi De Bao, Bao Chi Liu, Ai Qun Wu, Dong Xie, Wan Cai Yang, Liang Wang, Xiao Hang Zhao, Shu Qing Chen, Jun Yan Hong, Xue Jun Zhang, Neal D. Freedman, Alisa M. Goldstein, Dongxin Lin, Philip R. Taylor, Li Dong Wang, Stephen J. Chanock

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.82-0.88; P = 7.72 × 10-20) and rs1642764 at 17p13.1 (per-allele OR = 0.88, 95% CI = 0.85-0.91; P = 3.10 × 10-13). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR = 1.33, 95% CI = 1.22-1.46; P = 1.99 × 10-10). Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus unique to the population in the Taihang Mountain region at high risk of ESCC.

Original languageEnglish (US)
Pages (from-to)1001-1006
Number of pages6
JournalNature genetics
Volume46
Issue number9
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Genetics

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