Jejunal fluid and electrolyte secretion in carcinoid syndrome

Mark Donowitz, Henry J. Binder

Research output: Contribution to journalArticlepeer-review


To evaluate the pathogenesis of the diarrhea of carcinoid syndrome, triplelumen jejunal-perfusion studies were performed in three patients with carcinoid syndrome and diarrhea and eleven control subjects. In contrast to the net absorption observed in the control subjects during perfusion with an iso-tonic mannitol-saline solution, net secretion occurred in two of the three carcinoid-syndrome patients. Glucose absorption and glucose-stimulated fluid absorption were normal in the carcinoid-syndrome patients. Methysergide controlled the diarrhea and in one patient net absorption was observed during methysergide therapy. These studies suggest that intestinal secretion may be one of the pathogenetic factors responsible for the diarrhea of carcinoid syndrome and provide additional evidence of the importance of intestinal electrolyte secretion in the genesis of many diarrheal states.

Original languageEnglish (US)
Pages (from-to)1115-1122
Number of pages8
JournalThe American Journal of Digestive Diseases
Issue number12
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology


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