Japanese encephalitis: Idenufication of inflammatory cells in cerebrospinal fluid

Richard T. Johnson, Pensri Intralawan, Siriraj Puapanwatton

Research output: Contribution to journalArticlepeer-review

Abstract

Fifteen patients with acute encephalitis were studied during the epidemic season of Japanese encephalitis (JE) in Northern Thailand; 13 of 15 proved to have the encephalitis. In serial cerebrospinal fluids and blood samples, mononuclear cells were identified using monoclonal antibodies. In cerebrospinal fluid from the patients with Japanese encephalitis, T cells predominated with a 4.2:1 ratio of T helper/inducer cells to T suppressor/cytotoxic cells; B cells and macrophages were often present but in small numbers compared to their presence in blood. Distribution of cell types did not vary between the first and fifth day of hospitalization, were similar in fatal and nonfatal cases, and were unaffected by administration of steroids.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalAnnals of neurology
Volume20
Issue number6
DOIs
StatePublished - Dec 1986

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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