Jak-STAT signaling induced by the v-abl oncogene

Nika N. Danial, Alessandra Pernis, Paul B. Rothman

Research output: Contribution to journalArticle

Abstract

The effect of the v-abl oncogene of the Abelson murine leukemia virus (A-MuLV) on the Jak-STAT pathway of cytokine signal transduction was investigated. In murine pre-B lymphocytes transformed with A-MuLV, the Janus kinases (Jaks) Jaki and Jak3 exhibited constitutive tyrosine kinase activity, and the STAT proteins (signal transducers and activators of transcription) normally activated by interleukin-4 and interleukin-7 were tyrosine- phosphorylated in the absence of these cytokines. Coimmunoprecipitation experiments revealed that in these cells v-Abl was physically associated with Jaki and Jak3. Inactivation of v-Abl tyrosine kinase in a pre-B cell line transformed with a temperaturesensitive mutant of v-abl resulted in abrogation of constitutive Jak-STAT signaling. A direct link may exist between transformation by v-abl and cytokine signal transduction.

Original languageEnglish (US)
Pages (from-to)1875-1877
Number of pages3
JournalScience
Volume269
Issue number5232
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • General

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