JAK-STAT signaling in stem cells

Rachel R. Stine, Erika L. Matunis

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations


Adult stem cells are essential for the regeneration and repair of tissues in an organism. Signals from many different pathways converge to regulate stem cell maintenance and differentiation while preventing overproliferation. Although each population of adult stem cells is unique, common themes arise by comparing the regulation of various stem cell types in an organism or by comparing similar stem cell types across species. The JAK-STAT signaling pathway, identified nearly two decades ago, is now known to be involved in many biological processes including the regulation of stem cells. Studies in Drosophila first implicated JAK-STAT signaling in the control of stem cell maintenance in the male germline stem cell microenvironment, or niche; subsequently it has been shown play a role in other niches in both Drosophila and mammals. In this chapter, we will address the role of JAK-STAT signaling in stem cells in the germline, intestinal, hematopoietic and neuronal niches in Drosophila as well as the hematopoietic and neuronal niches in mammals. We will comment on how the study of JAK-STAT signaling in invertebrate systems has helped to advance our understanding of signaling in vertebrates. In addition to the role of JAK-STAT signaling in stem cell niche homeostasis, we will also discuss the diseases, including cancers, that can arise when this pathway is misregulated.

Original languageEnglish (US)
Title of host publicationTranscriptional and Translational Regulation of Stem Cells
PublisherSpringer New York LLC
Number of pages21
ISBN (Print)9789400766204
StatePublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


  • Germ line stem cell
  • Hematopoietic stem cell
  • Intestinal stem cell
  • JAK-STAT signaling
  • Neural stem cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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