TY - CHAP
T1 - JAK-STAT signaling in stem cells
AU - Stine, Rachel R.
AU - Matunis, Erika L.
PY - 2013
Y1 - 2013
N2 - Adult stem cells are essential for the regeneration and repair of tissues in an organism. Signals from many different pathways converge to regulate stem cell maintenance and differentiation while preventing overproliferation. Although each population of adult stem cells is unique, common themes arise by comparing the regulation of various stem cell types in an organism or by comparing similar stem cell types across species. The JAK-STAT signaling pathway, identified nearly two decades ago, is now known to be involved in many biological processes including the regulation of stem cells. Studies in Drosophila first implicated JAK-STAT signaling in the control of stem cell maintenance in the male germline stem cell microenvironment, or niche; subsequently it has been shown play a role in other niches in both Drosophila and mammals. In this chapter, we will address the role of JAK-STAT signaling in stem cells in the germline, intestinal, hematopoietic and neuronal niches in Drosophila as well as the hematopoietic and neuronal niches in mammals. We will comment on how the study of JAK-STAT signaling in invertebrate systems has helped to advance our understanding of signaling in vertebrates. In addition to the role of JAK-STAT signaling in stem cell niche homeostasis, we will also discuss the diseases, including cancers, that can arise when this pathway is misregulated.
AB - Adult stem cells are essential for the regeneration and repair of tissues in an organism. Signals from many different pathways converge to regulate stem cell maintenance and differentiation while preventing overproliferation. Although each population of adult stem cells is unique, common themes arise by comparing the regulation of various stem cell types in an organism or by comparing similar stem cell types across species. The JAK-STAT signaling pathway, identified nearly two decades ago, is now known to be involved in many biological processes including the regulation of stem cells. Studies in Drosophila first implicated JAK-STAT signaling in the control of stem cell maintenance in the male germline stem cell microenvironment, or niche; subsequently it has been shown play a role in other niches in both Drosophila and mammals. In this chapter, we will address the role of JAK-STAT signaling in stem cells in the germline, intestinal, hematopoietic and neuronal niches in Drosophila as well as the hematopoietic and neuronal niches in mammals. We will comment on how the study of JAK-STAT signaling in invertebrate systems has helped to advance our understanding of signaling in vertebrates. In addition to the role of JAK-STAT signaling in stem cell niche homeostasis, we will also discuss the diseases, including cancers, that can arise when this pathway is misregulated.
KW - Germ line stem cell
KW - Hematopoietic stem cell
KW - Intestinal stem cell
KW - JAK-STAT signaling
KW - Neural stem cell
UR - http://www.scopus.com/inward/record.url?scp=84934443712&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84934443712&partnerID=8YFLogxK
U2 - 10.1007/978-94-7-6621-1_14
DO - 10.1007/978-94-7-6621-1_14
M3 - Chapter
C2 - 23696361
AN - SCOPUS:84934443712
SN - 9789400766204
T3 - Advances in Experimental Medicine and Biology
SP - 247
EP - 267
BT - Transcriptional and Translational Regulation of Stem Cells
PB - Springer New York LLC
ER -