TY - JOUR
T1 - JAK-STAT signal inhibition regulates competition in the drosophila testis stem cell niche
AU - Lssigonis, Melanie
AU - Tulina, Natalia
AU - De Cuevas, Margaret
AU - Brawley, Crista
AU - Sandler, Laurel
AU - Matunist, Erika
PY - 2009
Y1 - 2009
N2 - Adult stem cells often reside in local microenvironments, or niches. Although niches can contain multiple types of stem cells, the coordinate regulation of stem cell behavior is poorly understood. In the Drosophila testis, Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling is directly required for maintenance of the resident germline and somatic stem cells. We found that the JAK-STAT signaling target and inhibitor Suppressor of cytokine signaling 36E (SOCS36E) is required for germline stem cell maintenance. SOCS36E suppresses JAK-STAT signaling specifically in the somatic stem cells, preventing them from displacing neighboring germline stem cells in a manner that depends on the adhesion protein integrin. Thus, in niches housing multiple stem cell types, negative feedback loops can modulate signaling, preventing one stem cell population from outcompeting the other.
AB - Adult stem cells often reside in local microenvironments, or niches. Although niches can contain multiple types of stem cells, the coordinate regulation of stem cell behavior is poorly understood. In the Drosophila testis, Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling is directly required for maintenance of the resident germline and somatic stem cells. We found that the JAK-STAT signaling target and inhibitor Suppressor of cytokine signaling 36E (SOCS36E) is required for germline stem cell maintenance. SOCS36E suppresses JAK-STAT signaling specifically in the somatic stem cells, preventing them from displacing neighboring germline stem cells in a manner that depends on the adhesion protein integrin. Thus, in niches housing multiple stem cell types, negative feedback loops can modulate signaling, preventing one stem cell population from outcompeting the other.
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U2 - 10.1126/science.1176817
DO - 10.1126/science.1176817
M3 - Article
C2 - 19797664
AN - SCOPUS:70349690282
SN - 0036-8075
VL - 326
SP - 153
EP - 156
JO - Science
JF - Science
IS - 5949
ER -