Ivermectin treatment of patients with severe ocular onchocerciasis

H. R. Taylor, Richard David Semba, H. S. Newland, E. Keyvan-Larijani, A. White, Z. Dukuly, B. M. Greene

Research output: Contribution to journalArticle

Abstract

The treatment of onchocerciasis with diethylcarbamazine and suramin is associated with an exacerbation of ocular disease. This occurs more frequently in patients with severe onchocercal ocular disease. We assessed ocular changes following ivermectin treatment in 39 patients with severe ocular onchocerciasis. Patients were treated with 100, 150, or 200 μg/kg of ivermectin at either 1 or 2 year intervals and followed for 3 years. There was no evidence for an acute exacerbation of either anterior or posterior segment eye disease, and there was a marked improvement in ocular status in the group as a whole. There was a significant decrease in onchocercal involvement which was maintained for at least 3 years. Annual treatment with ivermectin can be used safely in patients with severe ocular disease and is beneficial over a prolonged period of time.

Original languageEnglish (US)
Pages (from-to)494-500
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume40
Issue number5
StatePublished - 1989

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Ocular Onchocerciasis
Ivermectin
Eye Diseases
Diethylcarbamazine
Onchocerciasis
Suramin
Therapeutics

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Taylor, H. R., Semba, R. D., Newland, H. S., Keyvan-Larijani, E., White, A., Dukuly, Z., & Greene, B. M. (1989). Ivermectin treatment of patients with severe ocular onchocerciasis. American Journal of Tropical Medicine and Hygiene, 40(5), 494-500.

Ivermectin treatment of patients with severe ocular onchocerciasis. / Taylor, H. R.; Semba, Richard David; Newland, H. S.; Keyvan-Larijani, E.; White, A.; Dukuly, Z.; Greene, B. M.

In: American Journal of Tropical Medicine and Hygiene, Vol. 40, No. 5, 1989, p. 494-500.

Research output: Contribution to journalArticle

Taylor, HR, Semba, RD, Newland, HS, Keyvan-Larijani, E, White, A, Dukuly, Z & Greene, BM 1989, 'Ivermectin treatment of patients with severe ocular onchocerciasis', American Journal of Tropical Medicine and Hygiene, vol. 40, no. 5, pp. 494-500.
Taylor HR, Semba RD, Newland HS, Keyvan-Larijani E, White A, Dukuly Z et al. Ivermectin treatment of patients with severe ocular onchocerciasis. American Journal of Tropical Medicine and Hygiene. 1989;40(5):494-500.
Taylor, H. R. ; Semba, Richard David ; Newland, H. S. ; Keyvan-Larijani, E. ; White, A. ; Dukuly, Z. ; Greene, B. M. / Ivermectin treatment of patients with severe ocular onchocerciasis. In: American Journal of Tropical Medicine and Hygiene. 1989 ; Vol. 40, No. 5. pp. 494-500.
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