Itch mechanisms and circuits

Liang Han, Xinzhong Dong

Research output: Contribution to journalArticle

Abstract

The itch-scratch reflex serves as a protective mechanism in everyday life. However, chronic persistent itching can be devastating. Despite the clinical importance of the itch sensation, its mechanism remains elusive. In the past decade, substantial progress has been made to uncover the mystery of itching. Here, we review the molecules, cells, and circuits known to mediate the itch sensation, which, coupled with advances in understanding the pathophysiology of chronic itching conditions, will hopefully contribute to the development of new anti-itch therapies.

Original languageEnglish (US)
Pages (from-to)331-355
Number of pages25
JournalAnnual Review of Biophysics
Volume43
Issue number1
DOIs
StatePublished - 2014

Fingerprint

Pruritus
Molecules
Networks (circuits)
Reflex
Therapeutics

Keywords

  • Itch
  • Neural circuits
  • Neurons
  • Pain
  • Pruritus
  • Sensitization

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Structural Biology
  • Bioengineering

Cite this

Itch mechanisms and circuits. / Han, Liang; Dong, Xinzhong.

In: Annual Review of Biophysics, Vol. 43, No. 1, 2014, p. 331-355.

Research output: Contribution to journalArticle

Han, Liang ; Dong, Xinzhong. / Itch mechanisms and circuits. In: Annual Review of Biophysics. 2014 ; Vol. 43, No. 1. pp. 331-355.
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