TY - CHAP
T1 - ITC
T2 - More Than Just Binding Affinities
AU - Freire, Ernesto
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2011/2/24
Y1 - 2011/2/24
KW - Enthalpy and entropy, forces of binding - two forces, determining ligand to target binding
KW - Experimental observable in ITC - heat of reaction, binding enthalpy and entropy for reaction
KW - Heat associated with each injection - proportional to amount of complex formed
KW - ITC - more than just binding affinities
KW - ITC, measuring binding enthalpy - and binding entropy, tool for optimization of drug candidates
KW - Isothermal titration calorimetry (ITC) - gold standard, for measuring binding affinities
KW - Standard ITC titration experiments - binding reaction, injection of second reactant into reaction cell
KW - Thermodynamic signature - of candidate for optimization, measured by ITC
KW - Thermodynamic signatures - for rosuvastatin binding to HMG-CoA reductase
UR - http://www.scopus.com/inward/record.url?scp=84886139464&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886139464&partnerID=8YFLogxK
U2 - 10.1002/9780470979129.ch20
DO - 10.1002/9780470979129.ch20
M3 - Chapter
AN - SCOPUS:84886139464
SN - 9780470746837
SP - 303
EP - 312
BT - Label-Free Technologies for Drug Discovery
PB - John Wiley and Sons
ER -