Issues in the design of the fluconazole prophylaxis trials in patients undergoing hematopoietic stem cell transplantation

Research output: Contribution to journalArticle

Abstract

Today, invasive candidal infections are much less of a problem in patients undergoing hematopoietic stem cell transplantation (HSCT) than they wcere in the 1980s, principally because of widespread application of effective antifungal prophylaxis strategies. Two randomized, placebo-controlled studies performed in the early 1990s were instrumental in demonstrating the protective effects of fluconazole. Although both studies showed that candidiasis is prevented by fluconazole prophylaxis, controversies regarding optimal administration guidelines and the impact on survival after HSCT have persisted over the last decade. Details of how these trials were done, including the patients enrolled and end points evaluated, explain many of the different findings and controversies. An understanding of design issues can help explain current controversies and can assist in development of future prophylaxis studies.

Original languageEnglish (US)
Pages (from-to)S170-S175
JournalClinical Infectious Diseases
Volume39
Issue numberSUPPL. 4
DOIs
StatePublished - Oct 15 2004
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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