Issues in omics data integration for gene set analysis and aberrant pathway identification

Michael F. Ochs

Research output: Contribution to journalArticle

Abstract

The impact of omics technologies, from microarrays to next-generation sequencing, on drug development has been limited by our inability to integrate the data meaningfully for pathway analysis. Here we discuss the relationship between biomolecules and pathway activity, focusing on metabolic and signaling pathways. We discuss how each type of pathway requires a different approach to the generation of pathway statistics from omics data and provide guidance for the creation of appropriate gene sets for pathway analysis.

Original languageEnglish (US)
Pages (from-to)528-534
Number of pages7
JournalDrug Development Research
Volume73
Issue number8
DOIs
StatePublished - Dec 2012

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Keywords

  • biostatistics
  • cell signaling
  • gene set analysis
  • metabolic pathway
  • microarray

ASJC Scopus subject areas

  • Drug Discovery

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