TY - JOUR
T1 - Issues in Defining the Burden of Prediabetes Globally
AU - Echouffo-Tcheugui, Justin B.
AU - Kengne, Andre P.
AU - Ali, Mohammed K.
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Purpose of Review: Using a global perspective, this review collates evidence on the heterogeneity of prediabetes definitions and diagnostic methods, their clinical and public health implications, and discusses possible options for improvement. Recent Findings: Our review notes that the concept of prediabetes is increasingly recognized worldwide, but against a background of non-uniform definition and diagnostic criteria. This results in widely varying burden estimation. Summary: Current evidence shows a variety of prediabetes phenotypes. This reflects biological and diagnostic heterogeneity, resulting from the use of different tests (glucose or HbA1C) and thresholds to define prediabetes. The biological and diagnostic variabilities have implications for the characterization of the burden of prediabetes, natural history, prognosis, screening, implementation of lifestyle or drug interventions to mitigate related health risks, and monitoring of the effects of such interventions.
AB - Purpose of Review: Using a global perspective, this review collates evidence on the heterogeneity of prediabetes definitions and diagnostic methods, their clinical and public health implications, and discusses possible options for improvement. Recent Findings: Our review notes that the concept of prediabetes is increasingly recognized worldwide, but against a background of non-uniform definition and diagnostic criteria. This results in widely varying burden estimation. Summary: Current evidence shows a variety of prediabetes phenotypes. This reflects biological and diagnostic heterogeneity, resulting from the use of different tests (glucose or HbA1C) and thresholds to define prediabetes. The biological and diagnostic variabilities have implications for the characterization of the burden of prediabetes, natural history, prognosis, screening, implementation of lifestyle or drug interventions to mitigate related health risks, and monitoring of the effects of such interventions.
KW - Impaired fasting glucose
KW - Impaired glucose tolerance
KW - Normal glucose tolerance
KW - Prediabetes
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U2 - 10.1007/s11892-018-1089-y
DO - 10.1007/s11892-018-1089-y
M3 - Review article
C2 - 30229351
AN - SCOPUS:85053685555
SN - 1534-4827
VL - 18
JO - Current diabetes reports
JF - Current diabetes reports
IS - 11
M1 - 105
ER -