Isotretinoin in Lacrimal Gland Fluid and Tears

Vivian Rismondo

Research output: Contribution to journalArticle

Abstract

Isotretinoin (13-cis-retinoic acid) is used in the treatment of severe cystic acne. Adverse ocular reactions, including blepharoconjunctivitis and dry eye symptoms, are frequent side effects of this drug. Our previous observation that retinol is present in tears and lacrimal gland fluid suggests that isotretinoin may also be secreted by the lacrimal gland. Rabbits were treated with isotretinoin, and lacrimal gland fluid was collected from the cannulated lacrimal gland duct. Tears were collected from patients who were being treated with isotretinoin. Lacrimal gland fluid and tears were analyzed by reverse-phase high-pressure liquid chromatography and a peak eluted from each sample, which was identified as isotretinoin. We conclude that the lacrimal gland is able to secrete isotretinoin in addition to retinol and that, in animals and patients treated systemically with isotretinoin, the ocular surface is exposed to the drug via the tear film.

Original languageEnglish (US)
Pages (from-to)416-420
Number of pages5
JournalArchives of Ophthalmology
Volume105
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

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Isotretinoin
Lacrimal Apparatus
Tears
Vitamin A
Acne Vulgaris
Reverse-Phase Chromatography
Drug-Related Side Effects and Adverse Reactions
High Pressure Liquid Chromatography
Rabbits

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Isotretinoin in Lacrimal Gland Fluid and Tears. / Rismondo, Vivian.

In: Archives of Ophthalmology, Vol. 105, No. 3, 1987, p. 416-420.

Research output: Contribution to journalArticle

Rismondo, Vivian. / Isotretinoin in Lacrimal Gland Fluid and Tears. In: Archives of Ophthalmology. 1987 ; Vol. 105, No. 3. pp. 416-420.
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