Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer

Lalitha Ramachandran, Kanjoormana Aryan Manu, Muthu K. Shanmugam, Feng Li, Kodappully Sivaraman Siveen, Shireen Vali, Shweta Kapoor, Taher Abbasi, Rohit Surana, Duane T. Smoot, Hassan Ashktorab, Patrick Tan, Kwang Seok Ahn, Chun Wei Yap, Alan Prem Kumar, Gautam Sethi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: PPAR-γ, a nuclear transcription factor, plays a critical role in the development of gastric cancer (GC). Hence, novel agents that can modulate PPAR-γ cascade have a great potential for the treatment of GC. Results: Isorhamnetin (IH) modulates PPAR-γ pathway in GC. Conclusion: IH induces apoptosis through the activation of the PPAR-γ pathway. Significance: The study proposes a novel agent for GC treatment.

Original languageEnglish (US)
Pages (from-to)38028-38040
Number of pages13
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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