TY - JOUR
T1 - Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer
AU - Ramachandran, Lalitha
AU - Manu, Kanjoormana Aryan
AU - Shanmugam, Muthu K.
AU - Li, Feng
AU - Siveen, Kodappully Sivaraman
AU - Vali, Shireen
AU - Kapoor, Shweta
AU - Abbasi, Taher
AU - Surana, Rohit
AU - Smoot, Duane T.
AU - Ashktorab, Hassan
AU - Tan, Patrick
AU - Ahn, Kwang Seok
AU - Yap, Chun Wei
AU - Kumar, Alan Prem
AU - Sethi, Gautam
PY - 2012/11/2
Y1 - 2012/11/2
N2 - Background: PPAR-γ, a nuclear transcription factor, plays a critical role in the development of gastric cancer (GC). Hence, novel agents that can modulate PPAR-γ cascade have a great potential for the treatment of GC. Results: Isorhamnetin (IH) modulates PPAR-γ pathway in GC. Conclusion: IH induces apoptosis through the activation of the PPAR-γ pathway. Significance: The study proposes a novel agent for GC treatment.
AB - Background: PPAR-γ, a nuclear transcription factor, plays a critical role in the development of gastric cancer (GC). Hence, novel agents that can modulate PPAR-γ cascade have a great potential for the treatment of GC. Results: Isorhamnetin (IH) modulates PPAR-γ pathway in GC. Conclusion: IH induces apoptosis through the activation of the PPAR-γ pathway. Significance: The study proposes a novel agent for GC treatment.
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U2 - 10.1074/jbc.M112.388702
DO - 10.1074/jbc.M112.388702
M3 - Article
C2 - 22992727
AN - SCOPUS:84868314521
SN - 0021-9258
VL - 287
SP - 38028
EP - 38040
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 45
ER -