Isoniazid hair concentrations in children with tuberculosis: A proof of concept study

V. Mave, A. Chandanwale, A. Kinikar, S. Khadse, A. Kagal, N. NGupte, N. Suryavanshi, S. Nimkar, H. Koli, S. Khwaja, R. Bharadwaj, S. Joshi, H. Horng, L. Z. Benet, G. Ramachandran, K. E. Dooley, A. Gupta, M. Gandhi

Research output: Contribution to journalArticlepeer-review

Abstract

Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged ,12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandemmass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.

Original languageEnglish (US)
Pages (from-to)844-847
Number of pages4
JournalInternational Journal of Tuberculosis and Lung Disease
Volume20
Issue number6
DOIs
StatePublished - Jun 1 2016

Keywords

  • Hair assays
  • Isoniazid drug concentrations
  • Paediatric TB
  • Therapeutic drug monitoring
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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