Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Vidya Mave; Aarti Kinikar; Anju Kagal; Smita Nimkar; Hari Koli; Sultanat Khwaja; Renu Bharadwaj; Roy Gerona; Anita Wen; Geetha Ramachandran; Hemanth Kumar; Peter Bacchetti; Kelly Elise Dooley; Nikhil Gupte; Amita Gupta; Monica Gandhi

doi:10.1371/journal.pone.0189101

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Vidya Mave, Aarti Kinikar, Anju Kagal, Smita Nimkar, Hari Koli, Sultanat Khwaja, Renu Bharadwaj, Roy Gerona, Anita Wen, Geetha Ramachandran, Hemanth Kumar, Peter Bacchetti, Kelly Elise Dooley, Nikhil Gupte, Amita Gupta, Monica Gandhi

School of Medicine

Research output: Contribution to journal › Article

Abstract

We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, and 6 hours after drug administration). We found that INH levels in hair among highly-adherent individuals did not correlate well with plasma AUC or trough concentrations, suggesting that each measure may provide incremental and complementary information regarding drug exposure in the context of TB treatment.

Original language	English (US)
Article number	e0189101
Journal	PLoS One
Volume	12
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0189101
Publication status	Published - Dec 1 2017

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ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

Cite this

Mave, V., Kinikar, A., Kagal, A., Nimkar, S., Koli, H., Khwaja, S., ... Gandhi, M. (2017). Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis. PLoS One, 12(12), [e0189101]. https://doi.org/10.1371/journal.pone.0189101

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis. / Mave, Vidya; Kinikar, Aarti; Kagal, Anju; Nimkar, Smita; Koli, Hari; Khwaja, Sultanat; Bharadwaj, Renu; Gerona, Roy; Wen, Anita; Ramachandran, Geetha; Kumar, Hemanth; Bacchetti, Peter; Dooley, Kelly Elise ; Gupte, Nikhil ; Gupta, Amita; Gandhi, Monica.

In: PLoS One, Vol. 12, No. 12, e0189101, 01.12.2017.

Research output: Contribution to journal › Article

Mave, V, Kinikar, A, Kagal, A, Nimkar, S, Koli, H, Khwaja, S, Bharadwaj, R, Gerona, R, Wen, A, Ramachandran, G, Kumar, H, Bacchetti, P, Dooley, KE , Gupte, N , Gupta, A & Gandhi, M 2017, 'Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis', PLoS One, vol. 12, no. 12, e0189101. https://doi.org/10.1371/journal.pone.0189101

Mave, Vidya ; Kinikar, Aarti ; Kagal, Anju ; Nimkar, Smita ; Koli, Hari ; Khwaja, Sultanat ; Bharadwaj, Renu ; Gerona, Roy ; Wen, Anita ; Ramachandran, Geetha ; Kumar, Hemanth ; Bacchetti, Peter ; Dooley, Kelly Elise ; Gupte, Nikhil ; Gupta, Amita ; Gandhi, Monica. / Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis. In: PLoS One. 2017 ; Vol. 12, No. 12.

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