TY - JOUR
T1 - Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
AU - Mave, Vidya
AU - Kinikar, Aarti
AU - Kagal, Anju
AU - Nimkar, Smita
AU - Koli, Hari
AU - Khwaja, Sultanat
AU - Bharadwaj, Renu
AU - Gerona, Roy
AU - Wen, Anita
AU - Ramachandran, Geetha
AU - Kumar, Hemanth
AU - Bacchetti, Peter
AU - Dooley, Kelly E.
AU - Gupte, Nikhil
AU - Gupta, Amita
AU - Gandhi, Monica
N1 - Funding Information:
This study was primarily supported by JHU CFAR NIH/NIAID fund 1P30AI094189-01A1 and 1R21AI127149-01 (P.I. Mave). Data in this manuscript in part were collected as part of the Regional Prospective Observational Research for Tuberculosis (RePORT) India Consortium. This project has been funded in whole or in part with Federal funds from the Government of India’s (GOI) Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), the United States National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Office of AIDS Research (OAR), and distributed in part by CRDF Global. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the DBT, the ICMR, the NIH, or CRDF Global and R03 HD061059 (P.I. Jain S/Bharadwaj R). VM, NG, SM, HK, SK, AG are also supported by the NIH BWI Clinical Trials Unit for NIAID Networks (UM1) (P.I. Flexner/ Gupta, UM1AI069465). MG, RG, and AW are supported by NIAID/NIH 2RO1 AI098472 and hair assay development was partially supported by NIAID/NIH RO1AI123024. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Any mention of trade names, commercial projects, or organizations does not imply endorsement by any of the sponsoring organizations. The content of this paper is solely the responsibility of the authors and does not necessary represent the official views of the funders. We thank the study participants and study staff for their immense contribution.
PY - 2017/12
Y1 - 2017/12
N2 - We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, and 6 hours after drug administration). We found that INH levels in hair among highly-adherent individuals did not correlate well with plasma AUC or trough concentrations, suggesting that each measure may provide incremental and complementary information regarding drug exposure in the context of TB treatment.
AB - We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, and 6 hours after drug administration). We found that INH levels in hair among highly-adherent individuals did not correlate well with plasma AUC or trough concentrations, suggesting that each measure may provide incremental and complementary information regarding drug exposure in the context of TB treatment.
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U2 - 10.1371/journal.pone.0189101
DO - 10.1371/journal.pone.0189101
M3 - Article
C2 - 29216273
AN - SCOPUS:85037643550
VL - 12
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 12
M1 - e0189101
ER -