TY - JOUR
T1 - Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
AU - Mave, Vidya
AU - Kinikar, Aarti
AU - Kagal, Anju
AU - Nimkar, Smita
AU - Koli, Hari
AU - Khwaja, Sultanat
AU - Bharadwaj, Renu
AU - Gerona, Roy
AU - Wen, Anita
AU - Ramachandran, Geetha
AU - Kumar, Hemanth
AU - Bacchetti, Peter
AU - Dooley, Kelly E.
AU - Gupte, Nikhil
AU - Gupta, Amita
AU - Gandhi, Monica
N1 - Publisher Copyright:
© 2017 Mave et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/12
Y1 - 2017/12
N2 - We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, and 6 hours after drug administration). We found that INH levels in hair among highly-adherent individuals did not correlate well with plasma AUC or trough concentrations, suggesting that each measure may provide incremental and complementary information regarding drug exposure in the context of TB treatment.
AB - We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, and 6 hours after drug administration). We found that INH levels in hair among highly-adherent individuals did not correlate well with plasma AUC or trough concentrations, suggesting that each measure may provide incremental and complementary information regarding drug exposure in the context of TB treatment.
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U2 - 10.1371/journal.pone.0189101
DO - 10.1371/journal.pone.0189101
M3 - Article
C2 - 29216273
AN - SCOPUS:85037643550
SN - 1932-6203
VL - 12
JO - PloS one
JF - PloS one
IS - 12
M1 - e0189101
ER -