Isometric muscle strength in alcoholic and nonalcoholic liver- transplantation candidates

George Panzak, Ralph Tarter, Srinivas Murali, Jo Ann Switala, Sandra Lu, Brion Maher, David H. Van Thiel

Research output: Contribution to journalArticlepeer-review


Intensity of isometric muscle contractions was measured in alcoholic subjects with cirrhosis (N = 42), nonalcoholic subjects with cirrhosis (N = 33), and normal controls (N = 31). Muscle strength and endurance were comparable in the alcoholic and nonalcoholic cirrhotic subjects for all variables. Both cirrhotic groups were inferior to normal controls for all variables. The quantity X frequency (Q X F) index reported for the period during peak alcohol consumption correlated with 6 muscle-force variables, accounting for 9-20% of the variance. Alcoholic and nonalcoholic cirrhotic subjects did not differ in Quality of Life Inventory (QOLI) scales. Significant correlations, however, were found for the alcoholic cirrhotic subjects but not for the nonalcoholic cirrhotic subjects between quality-of- life indices and muscle strength and endurance. Muscle weakness is thus differentially associated with quality of life in alcoholic cirrhotic subjects as compared with nonalcoholic subjects with cirrhosis even though level of strength and endurance in the two groups is comparable.

Original languageEnglish (US)
Pages (from-to)499-512
Number of pages14
JournalAmerican Journal of Drug and Alcohol Abuse
Issue number3
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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