Isolation of Virus Related to SV40 from Patients with Progressive Multifocal Leukoencephalopathy

Leslie P. Weiner, Robert M. Herndon, Opendra Narayan, Richard T. Johnson, Keerti Shah, Lucien J. Rubinstein, Thomas J. Preziosi, Frances K. Conley

Research output: Contribution to journalArticle

Abstract

Virus related to simian-virus 40 (SV40) was isolated from brains of two patients with progressive multifocal leukoencephalopathy, a human demyelinating disease. Virus was grown in cell cultures of primary African green-monkey kidney inoculated with cultures of cells derived from patients' brains. Electron microscopy showed virus-like particles resembling papovaviruses in the brain of one patient and in monkey-kidney cell cultures infected with both virus isolates. Immunologic studies using fluorescent and neutralizing antibodies indicate a close relation between the isolated viruses and SV40.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalNew England Journal of Medicine
Volume286
Issue number8
DOIs
StatePublished - Feb 24 1972

ASJC Scopus subject areas

  • Medicine(all)

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    Weiner, L. P., Herndon, R. M., Narayan, O., Johnson, R. T., Shah, K., Rubinstein, L. J., Preziosi, T. J., & Conley, F. K. (1972). Isolation of Virus Related to SV40 from Patients with Progressive Multifocal Leukoencephalopathy. New England Journal of Medicine, 286(8), 385-390. https://doi.org/10.1056/NEJM197202242860801