Rodent x human hybrids containing single hitman chromosomes are valuable tools in the study of human genetics. Using a retrovirus carrying the neomycin gene, we generated a neomycin-resistant (ncor) pool of human diploid fibroblasts. Following fusion of microcells prepared from this pool to mouse A9 cells, we obtained four ncor hybrids containing a single human chromosome 2, 3, 5, or 15.
ASJC Scopus subject areas
- Molecular Biology