Isolation of monochromosomal hybrids following fusion of human diploid fibroblast-derived microcells with mouse A9 cells

Yi Ning, M. Lovell, L. Taylor, O. M. Pereira-Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Rodent x human hybrids containing single hitman chromosomes are valuable tools in the study of human genetics. Using a retrovirus carrying the neomycin gene, we generated a neomycin-resistant (ncor) pool of human diploid fibroblasts. Following fusion of microcells prepared from this pool to mouse A9 cells, we obtained four ncor hybrids containing a single human chromosome 2, 3, 5, or 15.

Original languageEnglish (US)
Pages (from-to)79-80
Number of pages2
JournalCytogenetic and Genome Research
Volume60
Issue number1
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Isolation of monochromosomal hybrids following fusion of human diploid fibroblast-derived microcells with mouse A9 cells'. Together they form a unique fingerprint.

Cite this