Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

José C. Aponte; Abraham J. Vaisberg; Rosario Rojas; Luz Caviedes; Walter H. Lewis; Gerardo Lamas; César Sarasara; Robert H. Gilman; Gerald B. Hammond

doi:10.1021/np070560c

Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

José C. Aponte, Abraham J. Vaisberg, Rosario Rojas, Luz Caviedes, Walter H. Lewis, Gerardo Lamas, César Sarasara, Robert H. Gilman, Gerald B. Hammond

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

Original language	English (US)
Pages (from-to)	102-105
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	1
DOIs	https://doi.org/10.1021/np070560c
State	Published - Jan 2008

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np070560c

Fingerprint Dive into the research topics of 'Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants'. Together they form a unique fingerprint.

Cite this

Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants. / Aponte, José C.; Vaisberg, Abraham J.; Rojas, Rosario; Caviedes, Luz; Lewis, Walter H.; Lamas, Gerardo; Sarasara, César; Gilman, Robert H.; Hammond, Gerald B.

In: Journal of Natural Products, Vol. 71, No. 1, 01.2008, p. 102-105.

Research output: Contribution to journal › Article › peer-review

@article{920d4692af5444d789e45cfc53be2715,

title = "Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants",

abstract = "The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.",

author = "Aponte, {Jos{\'e} C.} and Vaisberg, {Abraham J.} and Rosario Rojas and Luz Caviedes and Lewis, {Walter H.} and Gerardo Lamas and C{\'e}sar Sarasara and Gilman, {Robert H.} and Hammond, {Gerald B.}",

year = "2008",

month = jan,

doi = "10.1021/np070560c",

language = "English (US)",

volume = "71",

pages = "102--105",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

AU - Aponte, José C.

AU - Vaisberg, Abraham J.

AU - Rojas, Rosario

AU - Caviedes, Luz

AU - Lewis, Walter H.

AU - Lamas, Gerardo

AU - Sarasara, César

AU - Gilman, Robert H.

AU - Hammond, Gerald B.

PY - 2008/1

Y1 - 2008/1

N2 - The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

AB - The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

UR - http://www.scopus.com/inward/record.url?scp=39049164271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39049164271&partnerID=8YFLogxK

U2 - 10.1021/np070560c

DO - 10.1021/np070560c

M3 - Article

C2 - 18163590

AN - SCOPUS:39049164271

VL - 71

SP - 102

EP - 105

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 1

ER -