Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

José C. Aponte; Abraham J. Vaisberg; Rosario Rojas; Luz Caviedes; Walter H. Lewis; Gerardo Lamas; César Sarasara; Robert H. Gilman; Gerald B. Hammond

doi:10.1021/np070560c

Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

José C. Aponte, Abraham J. Vaisberg, Rosario Rojas, Luz Caviedes, Walter H. Lewis, Gerardo Lamas, César Sarasara, Robert H. Gilman, Gerald B. Hammond

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

Original language	English (US)
Pages (from-to)	102-105
Number of pages	4
Journal	Journal of Natural Products
Volume	71
Issue number	1
DOIs	https://doi.org/10.1021/np070560c
State	Published - Jan 2008

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np070560c

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Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants. / Aponte, José C.; Vaisberg, Abraham J.; Rojas, Rosario; Caviedes, Luz; Lewis, Walter H.; Lamas, Gerardo; Sarasara, César; Gilman, Robert H.; Hammond, Gerald B.

In: Journal of Natural Products, Vol. 71, No. 1, 01.2008, p. 102-105.

Research output: Contribution to journal › Article › peer-review

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title = "Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants",

abstract = "The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.",

author = "Aponte, {Jos{\'e} C.} and Vaisberg, {Abraham J.} and Rosario Rojas and Luz Caviedes and Lewis, {Walter H.} and Gerardo Lamas and C{\'e}sar Sarasara and Gilman, {Robert H.} and Hammond, {Gerald B.}",

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AU - Aponte, José C.

AU - Vaisberg, Abraham J.

AU - Rojas, Rosario

AU - Caviedes, Luz

AU - Lewis, Walter H.

AU - Lamas, Gerardo

AU - Sarasara, César

AU - Gilman, Robert H.

AU - Hammond, Gerald B.

PY - 2008/1

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N2 - The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

AB - The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

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Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

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