Abstract
The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2′,4′- dihydroxy-6′-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2′,4′-dihydroxy-4,6′-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.
Original language | English (US) |
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Pages (from-to) | 102-105 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 71 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2008 |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry