Isolation of a yeast artificial chromosome clone that spans the (12;16) translocation breakpoint characteristic of myxoid liposarcoma

Robert M. Gemmill, Michael J. Mendez, Cynthia M. Dougherty, Sylvie Paulien, Martha Liao, Deanna Mitchell, Sheryl A. Jankowski, Jeffrey M. Trent, Carol Berger, Avery A. Sandberg, Paul S. Meltzer

Research output: Contribution to journalArticlepeer-review

Abstract

Cytogenetic analysis of liposarcomas has demonstrated that translocation (12;16) (q13.3;p11.2) is characteristic of the myxoid subtype of this adipose tissue tumor. Our previous results suggested that the GLI gene is close to the translocation breakpoint on chromosome 12. We now describe a yeast artificial chromosome (YAC) that contains GLI and spans the chromosome 12 region involved in the t(12;16) breakpoint. This clone will permit rapid definition of the genetic region surrounding the breakpoint and allow isolation of the gene presumably affected by the translocation.

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume62
Issue number2
DOIs
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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