Isolation of a cDNA clone encoding a zinc finger protein highly expressed in T-leukemia lines

Bei Yue Wu, Edward W. Hanley, Lawrence A. Turka, Gary J. Nabel

Research output: Contribution to journalArticlepeer-review

Abstract

A cDNA clone encoding a novel zinc finger protein expressed in lymphoid cells has been isolated. This protein contains 5 repeats of the C2H2 motif previously described in the Drosophila gap gene, Krüppel, which is involved in embryo segmentation. Northern blot analysis showed that the messenger RNA (mRNA) encoding this protein is expressed at high levels in a variety of T-leukemia cell lines, at lower levels in some B cells, but is not observed in nonlymphoid cells. Within the T lineage, the mRNA is found at high levels in both αβ and γδ cells. These data suggest that this cDNA, designated Hkr-T1, represents a gene that may contribute to the determination of the differentiation and the specificity within lymphoid cells.

Original languageEnglish (US)
Pages (from-to)2571-2576
Number of pages6
JournalBlood
Volume80
Issue number10
StatePublished - Nov 15 1992
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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