Isolation of a cartilage factor that inhibits tumor neovascularization

Robert Langer; Henry Brem; Kenneth Falterman; Michael Klein; Judah Folkman

doi:10.1126/science.935859

Isolation of a cartilage factor that inhibits tumor neovascularization

Robert Langer, Henry Brem, Kenneth Falterman, Michael Klein, Judah Folkman

Research output: Contribution to journal › Article › peer-review

253 Scopus citations

Abstract

A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.

Original language	English (US)
Pages (from-to)	70-72
Number of pages	3
Journal	Science
Volume	193
Issue number	4247
DOIs	https://doi.org/10.1126/science.935859
State	Published - 1976
Externally published	Yes

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title = "Isolation of a cartilage factor that inhibits tumor neovascularization",

abstract = "A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.",

author = "Robert Langer and Henry Brem and Kenneth Falterman and Michael Klein and Judah Folkman",

year = "1976",

doi = "10.1126/science.935859",

language = "English (US)",

volume = "193",

pages = "70--72",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - Isolation of a cartilage factor that inhibits tumor neovascularization

AU - Langer, Robert

AU - Brem, Henry

AU - Falterman, Kenneth

AU - Klein, Michael

AU - Folkman, Judah

PY - 1976

Y1 - 1976

N2 - A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.

AB - A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.

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U2 - 10.1126/science.935859

DO - 10.1126/science.935859

M3 - Article

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AN - SCOPUS:0017098576

SN - 0036-8075

VL - 193

SP - 70

EP - 72

JO - Science

JF - Science

IS - 4247

ER -

Isolation of a cartilage factor that inhibits tumor neovascularization

Abstract

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