Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A

George R. Pettit; Daniel E. Schaufelberger

doi:10.1021/np50060a009

Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A

George R. Pettit, Daniel E. Schaufelberger

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

An unusual cytostatic (PS ED₅₀4 μg/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and designated phyllanthostatin A {1}. Separation of an MeOH extract of the root by size exclusion chromatography, high speed counter-current distribution, and semipreparative hplc afforded glycoside 1 in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin B [4]. The structure of lignan glycoside 1 was determined by hrfabms and 2D-nmr spectroscopy.

Original language	English (US)
Pages (from-to)	1104-1112
Number of pages	9
Journal	Journal of Natural Products
Volume	51
Issue number	6
DOIs	https://doi.org/10.1021/np50060a009
State	Published - Nov 1988
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50060a009

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title = "Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A",

abstract = "An unusual cytostatic (PS ED504 μg/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and designated phyllanthostatin A {1}. Separation of an MeOH extract of the root by size exclusion chromatography, high speed counter-current distribution, and semipreparative hplc afforded glycoside 1 in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin B [4]. The structure of lignan glycoside 1 was determined by hrfabms and 2D-nmr spectroscopy.",

author = "Pettit, {George R.} and Schaufelberger, {Daniel E.}",

year = "1988",

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AU - Schaufelberger, Daniel E.

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N2 - An unusual cytostatic (PS ED504 μg/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and designated phyllanthostatin A {1}. Separation of an MeOH extract of the root by size exclusion chromatography, high speed counter-current distribution, and semipreparative hplc afforded glycoside 1 in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin B [4]. The structure of lignan glycoside 1 was determined by hrfabms and 2D-nmr spectroscopy.

AB - An unusual cytostatic (PS ED504 μg/ml) lignan ester has been isolated from the Central American tree Phyllanthus acuminatus and designated phyllanthostatin A {1}. Separation of an MeOH extract of the root by size exclusion chromatography, high speed counter-current distribution, and semipreparative hplc afforded glycoside 1 in 0.007% yield. In solution, phyllanthostatin A was slowly transformed into justicidin B [4]. The structure of lignan glycoside 1 was determined by hrfabms and 2D-nmr spectroscopy.

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Isolation and structure of the cytostatic lignan glycoside phyllanthostatin A

Abstract

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