Isolation and structure elucidation of epipolasterol and 22,23-dihydroepipolasterol from the marine sponge Epipolasis sp.

Russell G. Kerr; Cathy Foss; Shigeki Matsunaga; Nobuhiro Fusetani

doi:10.1016/S0305-0491(97)00012-6

Isolation and structure elucidation of epipolasterol and 22,23-dihydroepipolasterol from the marine sponge Epipolasis sp.

Russell G. Kerr, Cathy Foss, Shigeki Matsunaga, Nobuhiro Fusetani

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Two new sterols, epipolasterol and 22(23)-dihydroepipolasterol, have been isolated from the marine sponge Epipolasis sp. These are unusual metabolites as they both contain a t-butyl group in the sterol side chain. In addition, the presence of two degrees of unsaturation in the side chain of epipolasterol is rare. The known sterol, 22-dehydro-24-isopropylcholesterol was also found in this sponge.

Original language	English (US)
Pages (from-to)	561-563
Number of pages	3
Journal	Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Volume	117
Issue number	4
DOIs	https://doi.org/10.1016/S0305-0491(97)00012-6
State	Published - 1997
Externally published	Yes

Keywords

Biosynthesis
Epipolasis
Epipolasterol
Marine
Sponge
Sterol

ASJC Scopus subject areas

Biochemistry
Physiology
Molecular Biology

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10.1016/S0305-0491(97)00012-6

Cite this

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title = "Isolation and structure elucidation of epipolasterol and 22,23-dihydroepipolasterol from the marine sponge Epipolasis sp.",

abstract = "Two new sterols, epipolasterol and 22(23)-dihydroepipolasterol, have been isolated from the marine sponge Epipolasis sp. These are unusual metabolites as they both contain a t-butyl group in the sterol side chain. In addition, the presence of two degrees of unsaturation in the side chain of epipolasterol is rare. The known sterol, 22-dehydro-24-isopropylcholesterol was also found in this sponge.",

keywords = "Biosynthesis, Epipolasis, Epipolasterol, Marine, Sponge, Sterol",

author = "Kerr, {Russell G.} and Cathy Foss and Shigeki Matsunaga and Nobuhiro Fusetani",

note = "Funding Information: Financial support at Florida Atlantic University was provided by a Bristol-Myers Squibb Company Award of Research Corporation, and is gratefully acknowledged. We would like to thank Dr. A. Wright (Harbor Branch Oceanographic Institution, Florida) for performing some of the DEPT experiments.",

year = "1997",

doi = "10.1016/S0305-0491(97)00012-6",

language = "English (US)",

volume = "117",

pages = "561--563",

journal = "Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology",

issn = "0305-0491",

number = "4",

}

TY - JOUR

T1 - Isolation and structure elucidation of epipolasterol and 22,23-dihydroepipolasterol from the marine sponge Epipolasis sp.

AU - Kerr, Russell G.

AU - Foss, Cathy

AU - Matsunaga, Shigeki

AU - Fusetani, Nobuhiro

N1 - Funding Information: Financial support at Florida Atlantic University was provided by a Bristol-Myers Squibb Company Award of Research Corporation, and is gratefully acknowledged. We would like to thank Dr. A. Wright (Harbor Branch Oceanographic Institution, Florida) for performing some of the DEPT experiments.

PY - 1997

Y1 - 1997

N2 - Two new sterols, epipolasterol and 22(23)-dihydroepipolasterol, have been isolated from the marine sponge Epipolasis sp. These are unusual metabolites as they both contain a t-butyl group in the sterol side chain. In addition, the presence of two degrees of unsaturation in the side chain of epipolasterol is rare. The known sterol, 22-dehydro-24-isopropylcholesterol was also found in this sponge.

AB - Two new sterols, epipolasterol and 22(23)-dihydroepipolasterol, have been isolated from the marine sponge Epipolasis sp. These are unusual metabolites as they both contain a t-butyl group in the sterol side chain. In addition, the presence of two degrees of unsaturation in the side chain of epipolasterol is rare. The known sterol, 22-dehydro-24-isopropylcholesterol was also found in this sponge.

KW - Biosynthesis

KW - Epipolasis

KW - Epipolasterol

KW - Marine

KW - Sponge

KW - Sterol

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U2 - 10.1016/S0305-0491(97)00012-6

DO - 10.1016/S0305-0491(97)00012-6

M3 - Article

AN - SCOPUS:0030881573

SN - 0305-0491

VL - 117

SP - 561

EP - 563

JO - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

JF - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

IS - 4

ER -

Isolation and structure elucidation of epipolasterol and 22,23-dihydroepipolasterol from the marine sponge Epipolasis sp.

Abstract

Keywords

ASJC Scopus subject areas

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