Isolation and characterization of the α platelet-derived growth factor receptor from rat olfactory epithelium

K. H. Lee, D. F. Bowen-Pope, R. R. Reed

Research output: Contribution to journalArticle

Abstract

We have cloned and characterized a new member of the receptor tyrosine kinase family. The cDNA clone, isolated from a rat olfactory cDNA library, has considerable homology to the family of receptors that includes the colony-stimulating factor 1 receptor, the c-kit proto-oncogene, and the platelet-derived growth factor (PDGF) receptors. Analysis of DNA sequence homology, ligand-binding, and ligand-stimulated phoshorylation data suggests that this clone encodes the rat PDGF-A/B or α-receptor. Comparison of its sequence to those of other receptors allows us to postulate a mechanism for receptor dimerization and activation. The expression of the rat α-PDGF receptor in nonneuronal cells of the olfactory epithelium and in the olfactory bulb is consistent with a role for PDGF in glial cell generation.

Original languageEnglish (US)
Pages (from-to)2237-2246
Number of pages10
JournalMolecular and cellular biology
Volume10
Issue number5
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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