Isolation and characterization of an ornithine aminotransferase-related sequence (oatl3) mapping to 10q26

Michael T. Geraghty, William G. Kearns, Peter L. Pearson, David Valle

Research output: Contribution to journalArticle

Abstract

We used a near full-length human ornithine δ-aminotransferase cDNA, huOAT6, as a probe under low stringency hybridization conditions to identify a new autosomal ornithine δ-aminotransferase-related sequence (OATL3). Cloning and characterization of this sequence reveal it to be a partial nonprocessed pseudogene corresponding to exon 3 and flanking intronic sequences of the ornithine δ-aminotransferase structural gene. Using somatic cell hybrids and fluorescence in situ hybridization, we mapped OATL3 to 10q26, adjacent to the ornithine δ-aminotransferase structural gene locus.

Original languageEnglish (US)
Pages (from-to)510-513
Number of pages4
JournalGenomics
Volume17
Issue number2
DOIs
StatePublished - Aug 1993

ASJC Scopus subject areas

  • Genetics

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