Isolated low HDL-cholesterol as an important risk factor for coronary heart disease

M. Miller, P. O. Kwiterovich

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Decreased levels of high density lipoprotein (HDL)-cholesterol are found in patients with hypertriglyceridaemia and in patients who have inherited disorders associated with premature coronary heart disease. Hereditary conditions associated with low levels of HDL-cholesterol and normal total cholesterol levels include familial hypoalphalipoproteinaemia, Tangier disease, fish eye disease, and lecithin:cholesterol acyltransferase deficiency. Secondary causes of low HDL-cholesterol levels include any condition that affects liver metabolism. A recent study of patients with coronary artery disease (CAD) who had normal levels of low density lipoprotein cholesterol and total cholesterol revealed that two-thirds of the men and four-fifths of the women had low HDL-cholesterol levels, suggesting that low HDL-cholesterol may be more prevalent than previously suspected. The high incidence of isolated hypoalphalipoproteinaemia in this group indicates that HDL-cholesterol measurements should be performed on all patients with CAD, regardless of their total cholesterol levels.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalEuropean heart journal
Issue numberSUPPL. H
StatePublished - 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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