TY - JOUR
T1 - Isolated low HDL-cholesterol as an important risk factor for coronary heart disease
AU - Miller, M.
AU - Kwiterovich, P. O.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - Decreased levels of high density lipoprotein (HDL)-cholesterol are found in patients with hypertriglyceridaemia and in patients who have inherited disorders associated with premature coronary heart disease. Hereditary conditions associated with low levels of HDL-cholesterol and normal total cholesterol levels include familial hypoalphalipoproteinaemia, Tangier disease, fish eye disease, and lecithin:cholesterol acyltransferase deficiency. Secondary causes of low HDL-cholesterol levels include any condition that affects liver metabolism. A recent study of patients with coronary artery disease (CAD) who had normal levels of low density lipoprotein cholesterol and total cholesterol revealed that two-thirds of the men and four-fifths of the women had low HDL-cholesterol levels, suggesting that low HDL-cholesterol may be more prevalent than previously suspected. The high incidence of isolated hypoalphalipoproteinaemia in this group indicates that HDL-cholesterol measurements should be performed on all patients with CAD, regardless of their total cholesterol levels.
AB - Decreased levels of high density lipoprotein (HDL)-cholesterol are found in patients with hypertriglyceridaemia and in patients who have inherited disorders associated with premature coronary heart disease. Hereditary conditions associated with low levels of HDL-cholesterol and normal total cholesterol levels include familial hypoalphalipoproteinaemia, Tangier disease, fish eye disease, and lecithin:cholesterol acyltransferase deficiency. Secondary causes of low HDL-cholesterol levels include any condition that affects liver metabolism. A recent study of patients with coronary artery disease (CAD) who had normal levels of low density lipoprotein cholesterol and total cholesterol revealed that two-thirds of the men and four-fifths of the women had low HDL-cholesterol levels, suggesting that low HDL-cholesterol may be more prevalent than previously suspected. The high incidence of isolated hypoalphalipoproteinaemia in this group indicates that HDL-cholesterol measurements should be performed on all patients with CAD, regardless of their total cholesterol levels.
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U2 - 10.1093/eurheartj/11.suppl_h.9
DO - 10.1093/eurheartj/11.suppl_h.9
M3 - Article
C2 - 2073916
AN - SCOPUS:0025681903
SN - 0195-668X
VL - 11
SP - 9
EP - 14
JO - European heart journal
JF - European heart journal
IS - SUPPL. H
ER -