Isolated endarteritis and kidney transplant survival: A multicenter collaborative study

Banff Working Group

Research output: Contribution to journalArticle

Abstract

Isolated endarteritis of kidney transplants is increasingly recognized. Notably, microarray studies revealed absence of immunologic signatures of rejection in most isolated endarteritis biopsy samples. We investigated if isolated endarteritis responds to rejection treatment and affects kidney transplant survival. We retrospectively enrolled recipients of kidney transplant who underwent biopsies between 1999 and 2011 at seven American and Canadian centers. Exclusion criteria were recipients were blood group-incompatible or crossmatch-positive or had C4d-positive biopsy samples. After biopsy confirmation, patients were divided into three groups: isolated endarteritis (n=103), positive controls (type I acute T cell-mediated rejection with endarteritis; n=101), and negative controls (no diagnostic rejection; n=103). Primary end points were improved kidney function after rejection treatment and transplant failure. Mean decrease in serum creatinine from biopsy to 1 month after rejection treatment was 132.6 μmol/L (95% confidence interval [95% CI], 78.7 to 186.5) in patients with isolated endarteritis, 96.4 μmol/L (95% CI, 48.6 to 143.2) in positive controls (P=0.32), and 18.6 μmol/L (95% CI, 1.8 to 35.4) in untreated negative controls (P

Original languageEnglish (US)
Pages (from-to)1216-1227
Number of pages12
JournalJournal of the American Society of Nephrology
Volume26
Issue number5
DOIs
Publication statusPublished - May 1 2015

    Fingerprint

ASJC Scopus subject areas

  • Nephrology

Cite this