Isoflavone dimers and other bioactive constituents from the figs of ficus mucuso

Jean J.K. Bankeu, Rustamova Khayala, Bruno N. Lenta, Didérot T. Noungoué, Silvère A. Ngouela, Sufyan A. Mustafa, Khalid Asaad, Mohammed I. Choudhary, Sean T. Prigge, Ralphreed Hasanov, Augustin E. Nkengfack, Etienne Tsamo, Muhammad S. Ali

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A - C (1 - 3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC50 0.68 μM) showed inh bitory activity on β-glucuronidase enzyme, while 3 (IC50 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).

Original languageEnglish (US)
Pages (from-to)1370-1378
Number of pages9
JournalJournal of Natural Products
Issue number6
StatePublished - Jun 24 2011

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


Dive into the research topics of 'Isoflavone dimers and other bioactive constituents from the figs of ficus mucuso'. Together they form a unique fingerprint.

Cite this