Isoflavone dimers and other bioactive constituents from the figs of ficus mucuso

Jean J.K. Bankeu, Rustamova Khayala, Bruno N. Lenta, Didérot T. Noungoué, Silvère A. Ngouela, Sufyan A. Mustafa, Khalid Asaad, Mohammed I. Choudhary, Sean T. Prigge, Ralphreed Hasanov, Augustin E. Nkengfack, Etienne Tsamo, Muhammad S. Ali

Research output: Contribution to journalArticle

Abstract

Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A - C (1 - 3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC50 0.68 μM) showed inh bitory activity on β-glucuronidase enzyme, while 3 (IC50 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).

Original languageEnglish (US)
Pages (from-to)1370-1378
Number of pages9
JournalJournal of Natural Products
Volume74
Issue number6
DOIs
StatePublished - Jun 24 2011

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Bankeu, J. J. K., Khayala, R., Lenta, B. N., Noungoué, D. T., Ngouela, S. A., Mustafa, S. A., Asaad, K., Choudhary, M. I., Prigge, S. T., Hasanov, R., Nkengfack, A. E., Tsamo, E., & Ali, M. S. (2011). Isoflavone dimers and other bioactive constituents from the figs of ficus mucuso. Journal of Natural Products, 74(6), 1370-1378. https://doi.org/10.1021/np100896w