Isoflavone dimers and other bioactive constituents from the figs of ficus mucuso

Jean J.K. Bankeu; Rustamova Khayala; Bruno N. Lenta; Didérot T. Noungoué; Silvère A. Ngouela; Sufyan A. Mustafa; Khalid Asaad; Mohammed I. Choudhary; Sean T. Prigge; Ralphreed Hasanov; Augustin E. Nkengfack; Etienne Tsamo; Muhammad S. Ali

doi:10.1021/np100896w

Isoflavone dimers and other bioactive constituents from the figs of ficus mucuso

Jean J.K. Bankeu, Rustamova Khayala, Bruno N. Lenta, Didérot T. Noungoué, Silvère A. Ngouela, Sufyan A. Mustafa, Khalid Asaad, Mohammed I. Choudhary, Sean T. Prigge, Ralphreed Hasanov, Augustin E. Nkengfack, Etienne Tsamo, Muhammad S. Ali

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A - C (1 - 3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC₅₀ 0.68 μM) showed inh bitory activity on β-glucuronidase enzyme, while 3 (IC₅₀ 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).

Original language	English (US)
Pages (from-to)	1370-1378
Number of pages	9
Journal	Journal of Natural Products
Volume	74
Issue number	6
DOIs	https://doi.org/10.1021/np100896w
State	Published - Jun 24 2011

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np100896w

Cite this

@article{fd51cdc2bc704b72995f19c2d6ea8dfb,

title = "Isoflavone dimers and other bioactive constituents from the figs of ficus mucuso",

abstract = "Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A - C (1 - 3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC50 0.68 μM) showed inh bitory activity on β-glucuronidase enzyme, while 3 (IC50 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).",

author = "Bankeu, {Jean J.K.} and Rustamova Khayala and Lenta, {Bruno N.} and Noungou{\'e}, {Did{\'e}rot T.} and Ngouela, {Silv{\`e}re A.} and Mustafa, {Sufyan A.} and Khalid Asaad and Choudhary, {Mohammed I.} and Prigge, {Sean T.} and Ralphreed Hasanov and Nkengfack, {Augustin E.} and Etienne Tsamo and Ali, {Muhammad S.}",

year = "2011",

month = jun,

day = "24",

doi = "10.1021/np100896w",

language = "English (US)",

volume = "74",

pages = "1370--1378",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Isoflavone dimers and other bioactive constituents from the figs of ficus mucuso

AU - Bankeu, Jean J.K.

AU - Khayala, Rustamova

AU - Lenta, Bruno N.

AU - Noungoué, Didérot T.

AU - Ngouela, Silvère A.

AU - Mustafa, Sufyan A.

AU - Asaad, Khalid

AU - Choudhary, Mohammed I.

AU - Prigge, Sean T.

AU - Hasanov, Ralphreed

AU - Nkengfack, Augustin E.

AU - Tsamo, Etienne

AU - Ali, Muhammad S.

PY - 2011/6/24

Y1 - 2011/6/24

N2 - Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A - C (1 - 3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC50 0.68 μM) showed inh bitory activity on β-glucuronidase enzyme, while 3 (IC50 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).

AB - Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A - C (1 - 3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (IC50 0.68 μM) showed inh bitory activity on β-glucuronidase enzyme, while 3 (IC50 7.69 μM) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).

UR - http://www.scopus.com/inward/record.url?scp=79959716446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959716446&partnerID=8YFLogxK

U2 - 10.1021/np100896w

DO - 10.1021/np100896w

M3 - Article

C2 - 21619045

AN - SCOPUS:79959716446

SN - 0163-3864

VL - 74

SP - 1370

EP - 1378

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

Isoflavone dimers and other bioactive constituents from the figs of ficus mucuso

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this