TY - JOUR
T1 - Isochromosomes in childhood acute lymphoblastic leukemia
T2 - A collaborative study of 83 cases
AU - Pui, Ching Hon
AU - Carroll, Andrew J.
AU - Raimondi, Susana C.
AU - Schell, Michael J.
AU - Head, David R.
AU - Shuster, Jonathan J.
AU - Crist, William M.
AU - Borowitz, Michael J.
AU - Link, Michael P.
AU - Behm, Frederick G.
AU - Steuber, C. Philip
AU - Land, Vita J.
PY - 1992/5/1
Y1 - 1992/5/1
N2 - Cytogenetic analysis of leukemic cells from 2,805 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified 83 cases (3%) that had a stemline with at least one isochromosome. The i(9q) was present in 28 (1%), the i(17q) in 23 (0.8%), and the i(7q) in 23 (0.8%). Other isochromosomes - i(21q), i(6p), i(1q), i(8q), or i(Xq) - were found in only 12 cases (0.4%). The isochromosome cases were more likely than were other ALL cases to have a pre-B immunophenotype (38% v 25%, P = .02) and leukemic cell hyperdiploidy >50 (37% v 24%, P = .02); five cases had both features. The i(9q) was associated with age greater than 10 years (P < .05) and the pre-B immunophenotype (P = .05); both the i(17q) and i(7q) had high frequencies of hyperdiploidy >50 (P < .0001 and P = .05, respectively). The t(1;19)(q23;p13) was a common feature (23%) in cases with the i(9q), i(7q), i(6p), or i(1q). These findings establish the i(9q), i(17q), and i(7q) as nonrandom chromosomal abnormalities in ALL. The prognostic significance of the presence of isochromosome(s) remains to be determined.
AB - Cytogenetic analysis of leukemic cells from 2,805 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified 83 cases (3%) that had a stemline with at least one isochromosome. The i(9q) was present in 28 (1%), the i(17q) in 23 (0.8%), and the i(7q) in 23 (0.8%). Other isochromosomes - i(21q), i(6p), i(1q), i(8q), or i(Xq) - were found in only 12 cases (0.4%). The isochromosome cases were more likely than were other ALL cases to have a pre-B immunophenotype (38% v 25%, P = .02) and leukemic cell hyperdiploidy >50 (37% v 24%, P = .02); five cases had both features. The i(9q) was associated with age greater than 10 years (P < .05) and the pre-B immunophenotype (P = .05); both the i(17q) and i(7q) had high frequencies of hyperdiploidy >50 (P < .0001 and P = .05, respectively). The t(1;19)(q23;p13) was a common feature (23%) in cases with the i(9q), i(7q), i(6p), or i(1q). These findings establish the i(9q), i(17q), and i(7q) as nonrandom chromosomal abnormalities in ALL. The prognostic significance of the presence of isochromosome(s) remains to be determined.
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M3 - Article
C2 - 1571550
AN - SCOPUS:0026720795
SN - 0006-4971
VL - 79
SP - 2384
EP - 2391
JO - Blood
JF - Blood
IS - 9
ER -