The incidence, type, and clonality of isochromosomes at diagnosis were investigated in acute lymphoblastic leukaemia (ALL). An isochromosome was detected in 50/1,035 (4.8%) of successfully karyotyped patients, 41/919 children (4.5%) and 9/116 adults (7.8%), who were diagnosed within a 5 year period. Isochromosomes of 21q with breakpoints in the short arm at p11 or in the long arm at q10 or q22 were identified in 15 patients (1.4%) associated with B-lineage immunophenotype, a white blood cell count (WBC) of < 10 x 109/litre, and pseudo- or low hyperdiploidy. Isochromosomes of 17q and 7q occurred in 13 (1.3%) and 9 (0.9%) patients, respectively, and were associated with high hyperdiploidy. Isochromosomes of 9q and 6p occurred in 6 (0.6%) and 5 (0.5%) patients, respectively, whereas i(Xp), i(Iq), and i(8q) occurred in I patient each. The isochromosome occurred as the sole abnormality in 4 patients [3 with i(21q) and I with i(7q)] and in the stemline, but with other chromosomal changes, in 35 patients. It was confined to a clonally evolved sideline in 11 patients. Isochromosomes occurred with established abnormalities in 7 patients: with t(1:19)-i(7q)/i(9q)/i(7q) and i(9q) each in 1 patient; with t(4:11)-i(7q)/i(17q) in 1 and 2 patients, respectively; and with t(9:22)-i(9q) in I patient. This study indicates that isochromosome formation can be an early chromosomal change and suggests that i(21q) occurs more frequently at diagnosis than has been previously suspected.
|Original language||English (US)|
|Number of pages||10|
|Journal||Genes Chromosomes and Cancer|
|State||Published - Sep 1996|
ASJC Scopus subject areas
- Cancer Research