Islet allograft, islet xenograft, and skin allograft survival in CD8+ T lymphocyte-deficient mice

N. M. Desai, H. Bassiri, J. Kim, B. H. Koller, O. Smithies, C. F. Barker, A. Naji, J. F. Markmann

Research output: Contribution to journalArticlepeer-review


Despite extensive study, the immunologic mechanisms mediating allograft rejection have not been completely defined. In the current study, we evaluated the T cell subsets important in islet allograft, skin allograft, and islet xenograft rejection using a genetically engineered line of mice deficient in β2-microglobulin expression. Because these mice lack cell surface MHC class I expression, they are deficient in T cells of the CD8 subset (class I-restricted cytotoxic T cells). Pancreatic islet allografts transplanted to CD8+ T cell-deficient recipients showed prolonged survival compared with controls. No prolongation was observed in the survival of pancreatic islet xenografts or in the survival of skin allografts transplanted to the CD8+ T cell-deficient hosts. We conclude that CD8+ T cells play a prominent role in islet allograft, but not islet xenograft or skin allograft, rejection in mice.

Original languageEnglish (US)
Pages (from-to)718-722
Number of pages5
Issue number4
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation


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