Ischemic optic neuropathies and their models: disease comparisons, model strengths and weaknesses

Steven L. Bernstein, Neil R. Miller

Research output: Contribution to journalReview articlepeer-review

Abstract

Ischemic optic neuropathies (IONs) describe a group of diseases that specifically target the optic nerve and result in sudden vision loss. These include nonarteritic and arteritic anterior ischemic optic neuropathy (NAION and AAION) and posterior ischemic optic neuropathy (NPION, APION). Until recently, little was known of the mechanisms involved in ION damage, due to a lack of information about the mechanisms associated with these diseases. This review discusses the new models that closely mimic these diseases (rodent NAION, primate NAION, rodent PION). These models have enabled closer dissection of the mechanisms involved with the pathophysiology of these disorders and enable identification of relevant mechanisms and potential pathways for effective therapeutic intervention. Descriptions of the different models are included, and comparisons between the models, their relative similarities with the clinical disease, as well as differences are discussed.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
JournalJapanese Journal of Ophthalmology
Volume59
Issue number3
DOIs
StatePublished - May 1 2015

Keywords

  • Arteritic anterior ischemic optic neuropathy model
  • Ischemic optic neuropathies
  • Nonarteritic anterior ischemic optic neuropathy
  • Optic nerve disease models
  • Posterior ischemic optic neuropathy

ASJC Scopus subject areas

  • Ophthalmology

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