Ischemic heart disease after renal transplantation

Bertram L. Kasiske, Jordan J. Cohen, John T. Harrington, Nicolaos E. Madias, Hamid Rabb, Mark Rosenberg, Charles A. Herzog, Michael Aaronson, Horacio Esteban Adrogué, Shakeel Anjum, Robert Berkseth

Research output: Contribution to journalArticle

Abstract

Dramatic improvements in renal allograft survival over the last 10 years have shifted the focus of posttransplant management from short-term considerations to reduction of deaths due to IHD (and other causes) over the long term. A growing body of evidence suggests that the high incidence of IHD after renal transplantation is in large part due to the high prevalence of traditional risk factors such as hypertension and hyperlipidemia. It is neither feasible nor necessary to demonstrate that treating risk factors like elevated blood pressure and LDL cholesterol is justified in reducing morbidity and mortality from IHD. Recent data suggest that the incidence of IHD is declining in some centers [16], likely because of the use of new medications that effectively reduce factors for IHD. Further emphasis on managing these risk factors, along with additional studies to identify new prevention strategies, are needed if progress in reducing this major cause of death in transplant patients is to continue.

Original languageEnglish (US)
Pages (from-to)356-369
Number of pages14
JournalKidney international
Volume61
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • HDL cholesterol
  • LDL cholesterol
  • Myocardial infarction

ASJC Scopus subject areas

  • Nephrology

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  • Cite this

    Kasiske, B. L., Cohen, J. J., Harrington, J. T., Madias, N. E., Rabb, H., Rosenberg, M., Herzog, C. A., Aaronson, M., Adrogué, H. E., Anjum, S., & Berkseth, R. (2002). Ischemic heart disease after renal transplantation. Kidney international, 61(1), 356-369. https://doi.org/10.1046/j.1523-1755.2002.00121.x