Ischemia-reperfusion and immediate T cell responses

Yanfei Huang, Hamid Rabb, Karl L. Womer

Research output: Contribution to journalArticle

Abstract

The pathogenesis of ischemia-reperfusion injury (IRI) is complex and not well understood. Inflammation plays an important role in IRI, with involvement of leukocytes, adhesion molecules, chemokines and cytokines. Emerging data suggest a role of T cells as mediators of IRI both in renal and extra-renal organs. Divergent roles of T cell subsets have also been elucidated, suggesting a more complicated role of T cells in the different phases of IRI. This review presents recent evidence from various animal models that advances our understanding of the role T cells play in IRI. These findings entertain the possibility of using immunotherapeutic agents for the prevention and treatment of IRI.

Original languageEnglish (US)
Pages (from-to)4-11
Number of pages8
JournalCellular Immunology
Volume248
Issue number1
DOIs
StatePublished - Jul 2007

Fingerprint

Reperfusion Injury
Reperfusion
Ischemia
T-Lymphocytes
Kidney
Cell Adhesion Molecules
T-Lymphocyte Subsets
Chemokines
Animal Models
Cytokines
Inflammation

Keywords

  • Inflammation
  • Ischemia
  • T cells

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Ischemia-reperfusion and immediate T cell responses. / Huang, Yanfei; Rabb, Hamid; Womer, Karl L.

In: Cellular Immunology, Vol. 248, No. 1, 07.2007, p. 4-11.

Research output: Contribution to journalArticle

Huang, Yanfei ; Rabb, Hamid ; Womer, Karl L. / Ischemia-reperfusion and immediate T cell responses. In: Cellular Immunology. 2007 ; Vol. 248, No. 1. pp. 4-11.
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