Ischemia-reperfusion and immediate T cell responses

Yanfei Huang, Hamid Rabb, Karl L. Womer

Research output: Contribution to journalArticle

Abstract

The pathogenesis of ischemia-reperfusion injury (IRI) is complex and not well understood. Inflammation plays an important role in IRI, with involvement of leukocytes, adhesion molecules, chemokines and cytokines. Emerging data suggest a role of T cells as mediators of IRI both in renal and extra-renal organs. Divergent roles of T cell subsets have also been elucidated, suggesting a more complicated role of T cells in the different phases of IRI. This review presents recent evidence from various animal models that advances our understanding of the role T cells play in IRI. These findings entertain the possibility of using immunotherapeutic agents for the prevention and treatment of IRI.

Original languageEnglish (US)
Pages (from-to)4-11
Number of pages8
JournalCellular Immunology
Volume248
Issue number1
DOIs
StatePublished - Jul 1 2007

Keywords

  • Inflammation
  • Ischemia
  • T cells

ASJC Scopus subject areas

  • Immunology

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